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Table 1 Summary of genomic studies on gastric cancer (GC)

From: Genomic alterations and molecular subtypes of gastric cancers in Asians

Reference Sample size Ethnicity Histology (Lauren’s type) Technology platform Molecular subtype
Intestinal Diffuse Mixed Not specified WES WGS RNAseq SNP/copy number microarray Targeted sequencing Gene expression microarray DNA methylation profiling
[10] 49 (MSS only) Korean 18 31 0 0        NA
[14] 294 Northern Chinese 139 155 0 0      High clonality and low clonality
[16] 75 Asian 196 69 19 11    EBV+, MSI, GS, and CIN
220 Non-Asian
[17] 890 Asian 0 0 0 1016        NA
126 Non-Asian
[18] 100 Chinese (Hong Kong) 57 29 14 0     NA
[22] 386 Singaporean 253 183 82 3        Genomic intestinal and genomic diffuse
65 Korean
70 Australian
[23] 19 Korean 5 14 0 0       NA
[24] 300 Korean 150 142 8 0      MSS/TP53, MSS/TP53+, MSS/EMT, and MSI
[25] 103 Korean 61 36 5 1       NA
[26] 22 Chinese (Hong Kong) 18 2 2 0        NA
[27] 15 Singaporean 11 3 1 0      NA
[28] 87 Japanese 0 87 0 0       NA
[29] 36 Non-Asian 12 10 14 0        Proximal non-diffuse, diffuse, and distal non-diffuse
[30] 17 Non-Asian 0 0 0 51      NA
34 Vietnamese
[31] 116 Non-Asian 12 24 0 80        NA
  1. WES whole-exome sequencing, WGS whole-genome sequencing, RNAseq RNA sequencing, SNP single-nucleotide polymorphism, MSS microsatellite stable, NA not available, EBV, Epstein-Barr virus, MSI microsatellite instability, GS genomically stable, CIN chromosomal instability, TP53 tumor protein 53, EMT epithelial-to-mesenchymal transition