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Table 6 Cox proportional regression analysis of associations between clinical characteristics and OS in 3893 patients with advanced NPC

From: A new prognostic histopathologic classification of nasopharyngeal carcinoma

Characteristic OS rate (%) Unadjusted HR 95% CI P value Adjusted HRa 95% CI P value
5-year 95% CI
Therapeutic modality
 RT 64.8 61.7–67.6 1.00 Reference   1.00 Reference  
 RCT 75.6 73.8–77.3 0.67 0.59–0.76 <0.001 0.64 0.56–0.72 <0.001
Proposed classification
 EC 78.3 76.5–80.0 1.00 Reference   1.00 Reference  
 MSEC 69.1 65.4–72.5 1.48 1.27–1.72 <0.001 1.43 1.22–1.67 <0.001
 SC 57.6 52.8–62.1 2.24 1.91–2.62 <0.001 2.13 1.81–2.51 <0.001
 SCC 46.4 37.8–54.5 3.14 2.49–3.96 <0.001 3.99 2.97–5.35 <0.001
Age
 ≤47 years 77.7 75.7–79.6 1.00 Reference   1.00 Reference  
 >47 years 66.8 64.4–69.1 1.58 1.39–1.78 <0.001 1.51 1.34–1.71 <0.001
Sex
 Male 71.5 69.7–73.3 1.00 Reference   1.00 Reference  
 Female 75.2 72.1–78.0 0.81 0.69–0.93 0.003 0.82 0.71–0.95 0.008
Clinical stage
 III 76.8 74.7–78.8 1.00 Reference   1.00 Reference  
 IV 68.3 66.0–70.5 1.38 1.22–1.56 <0.001 1.48 1.31–1.68 <0.001
WHO classification
 NKUC 72.6 70.8–74.2 1.00 Reference   1.00 Reference  
 NKDC 73.2 69.5–76.7 0.98 0.83–1.15 0.780 0.97 0.81–1.15 0.690
 KSCC 60.9 47.7–71.9 1.66 1.13–2.41 0.009 0.47 0.29–0.76 0.002
  1. NPC nasopharyngeal carcinoma, OS overall survival, CI confidence interval, HR hazard ratio, RT radiotherapy, RCT radiochemotherapy, EC epithelial carcinoma, MSEC mixed sarcomatoid-epithelial carcinoma, SC sarcomatoid carcinoma, SCC squamous cell carcinoma, WHO World Health Organization, NKUC non-keratinizing undifferentiated carcinoma, NKDC non-keratinizing differentiated carcinoma, KSCC keratinizing squamous cell carcinoma
  2. aAll models were adjusted for the proposed classification, age, sex, therapeutic modality, clinical stage, and WHO classification