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Table 5 Clinical characteristics of 3893 patients with advanced NPC who were treated with different therapeutic modalities

From: A new prognostic histopathologic classification of nasopharyngeal carcinoma

Characteristic

RT alone

RCT

P value

Total (cases)

1077

2816

Age (years)

  

<0.001†

 Median (range)

48 (11–90)

47 (10–85)

 

Follow-up time (months)

 

<0.001†

 Median (range)

60 (2–120)

52 (2–120)

 

Sex [cases (%)]

  

0.120*

 Male

785 (72.9)

2120 (75.3)

 

 Female

292 (27.1)

696 (24.7)

 

Clinical stage [cases (%)]

 

<0.001*

 III

685 (63.6)

1144 (40.6)

 

 IV

392 (36.4)

1672 (59.4)

 

Proposed classification [cases (%)]

 

<0.001*

 EC

622 (57.8)

1845 (65.5)

 

 MSEC

228 (21.2)

531 (18.9)

 

 SC

178 (16.5)

320 (11.3)

 

 SCC

49 (4.5)

120 (4.3)

 

WHO classification [cases (%)]

 

<0.001*

 NKUC

889 (82.5)

2215 (78.6)

 

 NKDC

160 (14.9)

560 (20.0)

 

 KSCC

28 (2.6)

41 (1.4)

 

OS rate (%)

  

<0.001§

 5-year (95% CI)

64.8 (61.7–67.6)

75.6 (73.8–77.3)

 
  1. NPC nasopharyngeal carcinoma, RT radiotherapy, RCT radiochemotherapy, EC epithelial carcinoma, MSEC mixed sarcomatoid-epithelial carcinoma, SC sarcomatoid carcinoma, SCC squamous cell carcinoma, WHO World Health Organization, NKUC non-keratinizing undifferentiated carcinoma, NKDC non-keratinizing differentiated carcinoma, KSCC keratinizing squamous cell carcinoma, OS overall survival, CI confidence interval
  2. * Chi square test
  3. †Student’s t test
  4. §Log-rank test