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Table 5 Clinical characteristics of 3893 patients with advanced NPC who were treated with different therapeutic modalities

From: A new prognostic histopathologic classification of nasopharyngeal carcinoma

Characteristic RT alone RCT P value
Total (cases) 1077 2816
Age (years)    <0.001
 Median (range) 48 (11–90) 47 (10–85)  
Follow-up time (months)   <0.001
 Median (range) 60 (2–120) 52 (2–120)  
Sex [cases (%)]    0.120*
 Male 785 (72.9) 2120 (75.3)  
 Female 292 (27.1) 696 (24.7)  
Clinical stage [cases (%)]   <0.001*
 III 685 (63.6) 1144 (40.6)  
 IV 392 (36.4) 1672 (59.4)  
Proposed classification [cases (%)]   <0.001*
 EC 622 (57.8) 1845 (65.5)  
 MSEC 228 (21.2) 531 (18.9)  
 SC 178 (16.5) 320 (11.3)  
 SCC 49 (4.5) 120 (4.3)  
WHO classification [cases (%)]   <0.001*
 NKUC 889 (82.5) 2215 (78.6)  
 NKDC 160 (14.9) 560 (20.0)  
 KSCC 28 (2.6) 41 (1.4)  
OS rate (%)    <0.001§
 5-year (95% CI) 64.8 (61.7–67.6) 75.6 (73.8–77.3)  
  1. NPC nasopharyngeal carcinoma, RT radiotherapy, RCT radiochemotherapy, EC epithelial carcinoma, MSEC mixed sarcomatoid-epithelial carcinoma, SC sarcomatoid carcinoma, SCC squamous cell carcinoma, WHO World Health Organization, NKUC non-keratinizing undifferentiated carcinoma, NKDC non-keratinizing differentiated carcinoma, KSCC keratinizing squamous cell carcinoma, OS overall survival, CI confidence interval
  2. * Chi square test
  3. Student’s t test
  4. §Log-rank test