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Table 1 Results of randomized and single-arm interstitial brachytherapy trials

From: Accelerated partial breast irradiation: advances and controversies

Reported trial Number of patients Treatment volume Source/dose Median follow-up (months) Ipsilateral recurrence rate (%) Outcome/complications
Wazer et al. [7] 32 Excision cavity + 2 cm 192Ir, 3.4 Gy BID to 34 Gy 33 3 8 with fat necrosis, 11 with grade 3–4 skin toxicity
Arthur et al. [8] 44 (31 HDR, 13 LDR) Lumpectomy cavity + 2 cm 192Ir, HDR: 3.4 Gy BID to 24 Gy; LDR: 50 cGy/h to 45 Gy 42 0 43% of LDR patients had radiation recall with adriamycin
Benitez et al. [9] 199 Lumpectomy bed + 1–2 cm LDR 125I, 0.52 Gy/h to 50 Gy; HDR 192Ir, 3.2-3.4 Gy BID to 32–34 Gy 68.4 1.2 11% fat necrosis, 90% good-excellent cosmesis
Ott et al. [1012] 274 Tumor bed + 2 cm 192Ir, PDR: at 0.6 Gy pulses to 50 Gy; HDR: 4 Gy BID to 32 Gy 63 2.9 2.6% ≥ grade 3 toxicity, 90% good to excellent cosmesis
Fentiman et al. [13] 50 Tumor bed + 2 cm 137Cs, 4 fractions, 4–6 h/day to 45 Gy 75.6 18 82% good to excellent cosmesis
Polgár et al. [14] 45 Tumor bed + 1–2 cm HDR 192Ir, 7 fractions of 4.33 or 5.2 Gy in 4 days to 30.3–36.4 Gy 133 8.9 77.8% with good to excellent cosmesis, 2.2% with fat necrosis
  1. BID twice daily, HDR high-dose-rate, LDR low-dose-rate, PDR pulsed-dose-rate