Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Table 5 Relationship between clinical characteristics and OS/DFS in patients with high HBV DNA level (≥2000 IU/mL), as determined by univariate and multivariate Cox regression analysis

Variable	OS				DFS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR	P value	HR (95 % CI)	P value	HR	P value	HR (95 % CI)	P value
Age (≥50 vs. <50 years)	1.329	0.186			1.384	0.055	Not significant
Gender (female vs. male)	1.087	0.795			0.914	0.737
HBeAg (positive vs. negative)	1.407	0.132			1.216	0.290
Tumor size (≥5 vs. <5 cm)	1.618	0.024	Not significant		1.618	0.004	1.650 (1.162–2.342)	0.005
Tumor number (multiple vs. single)	2.175	0.010	Not significant		1.796	0.028	2.104 (1.218–3.635)	0.008
Pathologic grades (IV/III/II/I)	1.365	0.070	1.613 (1.129–2.305)	0.009	1.100	0.476
Microvascular thrombus (yes vs. no)	2.038	0.010	2.688 (1.534–4.710)	0.001	1.128	0.640
Tumor capsule (without/incomplete/complete)	1.201	0.148			1.030	0.771
AFP (>25 vs. ≤25 ng/mL)	1.291	0.240			1.030	0.863
ALT (>40 vs. ≤40 IU/L)	1.064	0.774			1.088	0.621
AST (>45 vs. ≤45 IU/L)	1.657	0.018	Not significant		1.688	0.002	1.486 (1.057–2.090)	0.023
ALB (≥35 vs. <35 g/L)	0.294	0.008	Not significant		0.633	0.316
TBIL (>20.5 vs. ≤20.5 μmol/L)	1.566	0.077	Not significant		1.098	0.672
Prothrombin time (>13.5 vs. ≤13.5 s)	0.867	0.557			0.814	0.283
Antiviral treatment (yes vs. no)	0.499	0.001	0.475 (0.309–0.729)	0.001	0.710	0.042	Not significant	0.120
Recurrence (yes vs. no)	9.514	<0.001	9.954 (4.781–20.725)	<0.001

OS overall survival, DFS disease-free survival, CI confidence interval, HR hazard ratio, Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin

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