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Table 4 Relationship between clinical characteristics and OS/DFS in patients without antiviral treatment (n = 253), as determined by univariate and multivariate Cox regression analysis

From: Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Variable OS DFS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR P value HR (95 % CI) P value HR P value HR (95 % CI) P value
Age (≥50 vs. <50 years) 1.341 0.169    0.933 0.693   
Gender (female vs. male) 0.891 0.710    0.827 0.465   
HBeAg (positive vs. negative) 1.681 0.054 Not significant   1.716 0.019 Not significant  
HBV DNA (≥2000 vs. <2000 IU/mL) 2.056 0.001 1.589 (1.042–2.422) 0.031 1.840 0.001 1.705 (1.204–2.415) 0.003
Tumor size (≥5 vs. <5 cm) 1.820 0.006 1.689 (1.087–2.624) 0.020 1.655 0.005 1.713 (1.195–2.455) 0.003
Tumor number (multiple vs. single) 2.393 0.004 2.259 (1.223–4.172) 0.009 2.227 0.004 2.571 (1.470–4.499) 0.001
Pathologic grades (IV/III/II/I) 1.357 0.075 Not significant   1.288 0.074 Not significant  
Microvascular thrombus (yes vs. no) 2.915 0.001 2.587 (1.345–4.978) 0.004 1.969 0.021 1.192 (1.066–3.429) 0.030
Tumor capsule (without/incomplete/complete) 1.028 0.825    0.880 0.226   
AFP (>25 vs. ≤25 ng/mL) 1.252 0.302    1.064 0.728   
ALT (>40 vs. ≤40 IU/L) 1.539 0.041 Not significant   1.375 0.072 Not significant  
AST (>45 vs. ≤45 IU/L) 1.803 0.009 Not significant   1.687 0.006 Not significant  
ALB (≥35 vs. <35 g/L) 0.423 0.061 Not significant   0.643 0.291   
TBIL (>20.5 vs. ≤20.5 μmol/L) 0.919 0.780    1.126 0.618   
Prothrombin time (>13.5 vs. ≤13.5 s) 1.146 0.593    1.015 0.945   
Recurrence (yes vs. no) 6.671 <0.001 5.442 (3.091–9.582) <0.001     
  1. OS overall survival, DFS disease-free survival, CI confidence interval, HR hazard ratio, Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin