Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Table 4 Relationship between clinical characteristics and OS/DFS in patients without antiviral treatment (n = 253), as determined by univariate and multivariate Cox regression analysis

Variable	OS				DFS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR	P value	HR (95 % CI)	P value	HR	P value	HR (95 % CI)	P value
Age (≥50 vs. <50 years)	1.341	0.169			0.933	0.693
Gender (female vs. male)	0.891	0.710			0.827	0.465
HBeAg (positive vs. negative)	1.681	0.054	Not significant		1.716	0.019	Not significant
HBV DNA (≥2000 vs. <2000 IU/mL)	2.056	0.001	1.589 (1.042–2.422)	0.031	1.840	0.001	1.705 (1.204–2.415)	0.003
Tumor size (≥5 vs. <5 cm)	1.820	0.006	1.689 (1.087–2.624)	0.020	1.655	0.005	1.713 (1.195–2.455)	0.003
Tumor number (multiple vs. single)	2.393	0.004	2.259 (1.223–4.172)	0.009	2.227	0.004	2.571 (1.470–4.499)	0.001
Pathologic grades (IV/III/II/I)	1.357	0.075	Not significant		1.288	0.074	Not significant
Microvascular thrombus (yes vs. no)	2.915	0.001	2.587 (1.345–4.978)	0.004	1.969	0.021	1.192 (1.066–3.429)	0.030
Tumor capsule (without/incomplete/complete)	1.028	0.825			0.880	0.226
AFP (>25 vs. ≤25 ng/mL)	1.252	0.302			1.064	0.728
ALT (>40 vs. ≤40 IU/L)	1.539	0.041	Not significant		1.375	0.072	Not significant
AST (>45 vs. ≤45 IU/L)	1.803	0.009	Not significant		1.687	0.006	Not significant
ALB (≥35 vs. <35 g/L)	0.423	0.061	Not significant		0.643	0.291
TBIL (>20.5 vs. ≤20.5 μmol/L)	0.919	0.780			1.126	0.618
Prothrombin time (>13.5 vs. ≤13.5 s)	1.146	0.593			1.015	0.945
Recurrence (yes vs. no)	6.671	<0.001	5.442 (3.091–9.582)	<0.001

OS overall survival, DFS disease-free survival, CI confidence interval, HR hazard ratio, Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin

ISSN: 2523-3548