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Table 2 Relationship between clinical characteristics and overall survival (OS)/disease-free survival (DFS), as determined by univariate and multivariate Cox regression analysis

From: Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Variable

OS

DFS

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

P value

HR (95 % CI)

P value

HR

P value

HR (95 % CI)

P value

Age (≥50 vs. <50 years)

1.320

0.101

  

1.116

0.401

  

Gender (female vs. male)

0.951

0.845

  

0.921

0.684

  

HBeAg (positive vs. negative)

1.582

0.020

Not significant

 

1.403

0.034

Not significant

 

HBV DNA (≥2000 vs. <2000 IU/mL)

1.580

0.009

1.615 (1.126–2.317)

0.009

1.511

0.002

1.496 (1.150–1.944)

0.003

Tumor size (≥5 vs. <5 cm)

1.745

0.001

Not significant

 

1.687

<0.001

1.868 (1.432–2.435)

<0.001

Tumor number (multiple vs. single)

2.347

<0.001

1.930 (1.196–3.113)

0.007

1.961

0.001

2.437 (1.607–3.696)

<0.001

Pathologic grade (IV/III/II/I)

1.413

0.014

1.412 (1.064–1.875)

0.017

1.172

0.145

  

Microvascular thrombus (yes vs. no)

2.076

0.002

2.339 (1.456–3.759)

<0.001

1.315

0.188

  

Tumor capsule (without/incomplete/complete)

1.123

0.244

  

0.950

0.520

  

AFP (>25 vs. ≤25 ng/mL)

1.181

0.335

  

1.079

0.568

  

ALT (>40 vs. ≤40 IU/L)

1.249

0.188

  

1.212

0.141

  

AST (>45 vs. ≤45 IU/L)

1.510

0.023

Not significant

 

1.597

0.001

Not significant

 

ALB (≥35 vs. <35 g/L)

0.358

0.008

0.383 (0.176–0.833)

0.015

0.661

0.250

  

TBIL (>20.5 vs. ≤20.5 μmol/L)

1.407

0.097

Not significant

 

1.227

0.222

  

Prothrombin time (>13.5 vs. ≤13.5 s)

1.051

0.799

  

1.011

0.942

  

Antiviral treatment (yes vs. no)

0.672

0.024

0.516 (0.359–0.743)

<0.001

0.969

0.809

  

Recurrence (yes vs. no)

7.785

<0.001

7.208 (4.418–11.760)

<0.001

    
  1. CI confidence interval, HR hazard ratio, Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin
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Cancer Communications

ISSN: 2523-3548

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