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Table 2 Relationship between clinical characteristics and overall survival (OS)/disease-free survival (DFS), as determined by univariate and multivariate Cox regression analysis

From: Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Variable OS DFS
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR P value HR (95 % CI) P value HR P value HR (95 % CI) P value
Age (≥50 vs. <50 years) 1.320 0.101    1.116 0.401   
Gender (female vs. male) 0.951 0.845    0.921 0.684   
HBeAg (positive vs. negative) 1.582 0.020 Not significant   1.403 0.034 Not significant  
HBV DNA (≥2000 vs. <2000 IU/mL) 1.580 0.009 1.615 (1.126–2.317) 0.009 1.511 0.002 1.496 (1.150–1.944) 0.003
Tumor size (≥5 vs. <5 cm) 1.745 0.001 Not significant   1.687 <0.001 1.868 (1.432–2.435) <0.001
Tumor number (multiple vs. single) 2.347 <0.001 1.930 (1.196–3.113) 0.007 1.961 0.001 2.437 (1.607–3.696) <0.001
Pathologic grade (IV/III/II/I) 1.413 0.014 1.412 (1.064–1.875) 0.017 1.172 0.145   
Microvascular thrombus (yes vs. no) 2.076 0.002 2.339 (1.456–3.759) <0.001 1.315 0.188   
Tumor capsule (without/incomplete/complete) 1.123 0.244    0.950 0.520   
AFP (>25 vs. ≤25 ng/mL) 1.181 0.335    1.079 0.568   
ALT (>40 vs. ≤40 IU/L) 1.249 0.188    1.212 0.141   
AST (>45 vs. ≤45 IU/L) 1.510 0.023 Not significant   1.597 0.001 Not significant  
ALB (≥35 vs. <35 g/L) 0.358 0.008 0.383 (0.176–0.833) 0.015 0.661 0.250   
TBIL (>20.5 vs. ≤20.5 μmol/L) 1.407 0.097 Not significant   1.227 0.222   
Prothrombin time (>13.5 vs. ≤13.5 s) 1.051 0.799    1.011 0.942   
Antiviral treatment (yes vs. no) 0.672 0.024 0.516 (0.359–0.743) <0.001 0.969 0.809   
Recurrence (yes vs. no) 7.785 <0.001 7.208 (4.418–11.760) <0.001     
  1. CI confidence interval, HR hazard ratio, Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin