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Table 1 Comparison of clinicopathologic characteristics between antiviral and non-antiviral groups

From: Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Characteristic Antiviral group (n = 192) Non-antiviral group (n = 253) P value
Age (years) 0.372a
 Mean ± SDb 47.9 ± 10.3 48.8 ± 11.8
 Median and rangeb 47 (24–76) 49 (23–79)
 <50 111 128
 ≥50 81 125
Gender 0.278
 Male 172 218
 Female 20 35
HBeAg 0.003
 Positive 48 35
 Negative 144 218
HBV DNA (IU/mL) <0.001
 <2000 51 154
 ≥2000 141 99
Tumor size (cm) 0.012a
 Mean ± SDb 4.7 ± 3.1 5.4 ± 3.2
 Rangeb 1.0–25.0 1.0–18.0
 <5 122 121
 ≥5 70 132
Tumor number 0.990
 Single 176 232
 Multiple 16 21
Pathologic grade 0.961
 I 12 21
 II 121 150
 III 58 80
 IV 1 2
Microvascular thrombus 0.054
 Yes 25 19
 No 167 234
Tumor capsule 0.271
 Complete 87 112
 Incomplete 60 66
 Without 45 75
TNM stage 0.083
 I 151 215
 II 41 38
AFP (ng/mL) 0.881
 ≤25 78 101
 >25 114 152
ALT (IU/L) 0.002a
 Mean ± SDb 49.8 ± 30.3 41.9 ± 24.6
 Rangeb 13.1–209.2 8.5–163.0
 ≤40 83 150
 >40 109 103
AST (IU/L) 0.115a
 Mean ± SDb 41.6 ± 25.2 38.2 ± 20.4
 Rangeb 8.0–263.0 15.0–168.0
 ≤45 138 189
 >45 54 64
ALB (g/L) 0.485a
 Mean ± SDb 43.1 ± 3.6 42.8 ± 4.0
 Rangeb 29.3–52.5 27.8–51.6
 <35 3 8
 ≥35 189 245
TBIL (μmol/L) 0.035a
 Mean ± SDb 15.9 ± 7.3 14.6 ± 5.6
 Rangeb 4.6–63.3 5.0–47.2
 ≤20.5 156 217
 >20.5 36 36
Prothrombin time (s) 0.215a
 Mean ± SDb 12.7 ± 1.5 12.5 ± 1.3
 Rangeb 9.6–19.1 9.4–17.4
 ≤13.5 139 207
 >13.5 53 46
Recurrence 0.489
 Yes 105 130
 No 87 123
Death 0.043
 Yes 51 90
 No 141 163
  1. Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin
  2. a t test used
  3. b Except for these values, other values are presented as the number of patients and were compared by the χ2 test