Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection

Table 1 Comparison of clinicopathologic characteristics between antiviral and non-antiviral groups

Characteristic	Antiviral group (n = 192)	Non-antiviral group (n = 253)	P value
Age (years)			0.372^a
Mean ± SD^b	47.9 ± 10.3	48.8 ± 11.8
Median and range^b	47 (24–76)	49 (23–79)
<50	111	128
≥50	81	125
Gender			0.278
Male	172	218
Female	20	35
HBeAg			0.003
Positive	48	35
Negative	144	218
HBV DNA (IU/mL)			<0.001
<2000	51	154
≥2000	141	99
Tumor size (cm)			0.012^a
Mean ± SD^b	4.7 ± 3.1	5.4 ± 3.2
Range^b	1.0–25.0	1.0–18.0
<5	122	121
≥5	70	132
Tumor number			0.990
Single	176	232
Multiple	16	21
Pathologic grade			0.961
I	12	21
II	121	150
III	58	80
IV	1	2
Microvascular thrombus			0.054
Yes	25	19
No	167	234
Tumor capsule			0.271
Complete	87	112
Incomplete	60	66
Without	45	75
TNM stage			0.083
I	151	215
II	41	38
AFP (ng/mL)			0.881
≤25	78	101
>25	114	152
ALT (IU/L)			0.002^a
Mean ± SD^b	49.8 ± 30.3	41.9 ± 24.6
Range^b	13.1–209.2	8.5–163.0
≤40	83	150
>40	109	103
AST (IU/L)			0.115^a
Mean ± SD^b	41.6 ± 25.2	38.2 ± 20.4
Range^b	8.0–263.0	15.0–168.0
≤45	138	189
>45	54	64
ALB (g/L)			0.485^a
Mean ± SD^b	43.1 ± 3.6	42.8 ± 4.0
Range^b	29.3–52.5	27.8–51.6
<35	3	8
≥35	189	245
TBIL (μmol/L)			0.035^a
Mean ± SD^b	15.9 ± 7.3	14.6 ± 5.6
Range^b	4.6–63.3	5.0–47.2
≤20.5	156	217
>20.5	36	36
Prothrombin time (s)			0.215^a
Mean ± SD^b	12.7 ± 1.5	12.5 ± 1.3
Range^b	9.6–19.1	9.4–17.4
≤13.5	139	207
>13.5	53	46
Recurrence			0.489
Yes	105	130
No	87	123
Death			0.043
Yes	51	90
No	141	163

Antiviral group resection plus postsurgical antiviral treatment group, Non-antiviral group resection alone group, HBV hepatitis B virus, SD standard deviation, HBeAg hepatitis B e antigen, TNM tumor-node-metastasis, AFP alpha-fetoprotein, ALT alanine aminotransferase, AST aspartate aminotransferase, ALB serum albumin, TBIL serum total bilirubin
^a t test used
^b Except for these values, other values are presented as the number of patients and were compared by the χ² test

ISSN: 2523-3548