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Fig. 1 | Chinese Journal of Cancer

Fig. 1

From: Mechanisms of vascularization in murine models of primary and metastatic tumor growth

Fig. 1

Vessel incorporation and glomeruloid body formation in the brain. a Frozen section of an experimental brain metastasis of the C38 colorectal carcinoma cell line. The section is stained for CD31 (vessels, green), laminin (basement membrane, red), and 4′,6-diamidino-2-phenylindole (DAPI; cell nuclei, blue). The DAPI staining shows that the tumor is located in the upper part of the picture. Arrowheads show the tumorparenchyma interface. The tumor mass “flows” around the vessels, thereby incorporating them (arrows). Vessel density is significantly lower and vessel diameter is larger in the intratumoral region than in the peritumoral tissue. Scale bar 100 µm. b Glomeruloid body formation after injection of tumor cells into the carotid artery. Simple loops (arrowheads) of the capillary (laminin, green) that develop in the vicinity of tumor cells (arrows) can be observed. Cell nuclei are stained by propidium iodide (red). Scale bar 20 µm. c Semi-thin cross section stained by toluidine-blue represents a glomeruloid body formed in a colony of human melanoma cells. There are several capillary lumens within the small tumor cell group. Scale bar 20 µm

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