From: Why some tumours trigger neovascularisation and others don’t: the story thus far
Proteins equally expressed in angiogenic and non-angiogenic tumours | Proteins up-regulated in angiogenic tumours | Proteins up-regulated in non-angiogenic tumours | |||
---|---|---|---|---|---|
Ontology | GO-ontology database | Ontology | GO-ontology database | Ontology | GO-ontology database |
Cell migration/sprouting angiogenesis GO.0002042 | Biological process | Immune response-activating signals GO.0002757 | Biological process | Regulation of synapses GO.0051965 | Biological process |
Endothelial cell migration GO.0043534 | Biological process | Immune response-regulating cell signaling GO.0002768 | Biological process | Axon guidance and neuronal regulation GO.0031290 GO.0007413 GO.0021952 GO.0021955 GO.0008038 | Biological process |
VEGF signaling pathways GO.0038084 | Biological process | Mesodermal cell differentiation GO.0048333 | Biological process | – | – |
– | – | Activation of immune response GO.0002253 | Biological process | – | – |
– | – | – | – | Positive regulation cell biogenesis GO.0044089 | Biological process |
– | – | Basement membrane GO.0005604 | Cell component | – | – |
– | – | Extracellular matrix part GO.0044420 | Cell component | Mitochondrial intermembrane space and matrix GO.0005758 GO.0005759 | Cell component |
– | – | Complex involve in cell adhesion GO.0098636 | Cell component | – | – |
PDGF receptor-binding GO.0005161 | Molecular function | Fibronectin- and extracellular matrix-binding GO.0001968 GO.0050840 | Molecular function | Ephrin receptor activity GO.0005003 | Molecular function |
Extracellular matrix-binding GO.0050840 | Molecular function | Notch-binding GO.0005112 | Molecular function | Carbonate dehydratase activity GO.0004089 | Molecular function |
– | – | – | – | Axon guidance GO.0008046 | Molecular function |