Long-term outcomes of a phase II randomized controlled trial comparing intensity-modulated radiotherapy with or without weekly cisplatin for the treatment of locally recurrent nasopharyngeal carcinoma

Table 1 Baseline characteristics of 69 patients with non-metastatic locally recurrent nasopharyngeal carcinoma (NPC)

Characteristic	CCRT group	RT group	P value^a
Characteristic	(n = 34)	(n = 35)	P value^a
Sex (cases)			0.490
Male	27	30
Female	7	5
Age (years)			0.812
Range	31–63	32–73
Median	42	48
Interval of recurrence (months)			0.587
Range	12–121	9–72
Median	26.5	30.0
Initial radiation dose (Gy)			0.545
Range	66–78	68–86
Median	70	72
Pathology (cases)			0.532
WHO type II	2	3
WHO type III	27	24
Diagnosed by clinical diagnosis (cases)	5	8
rT category^b			0.175
rT1	2	3
rT2	3	7
rT3	17	10
rT4	12	15
rN category^b			0.778
rN0	30	29
rN1	3	5
rN2	1	1
Clinical stage^b (cases)			0.448
I	2	3
II	4	7
III	16	10
IV	12	15
Pre-treatment serious complications^c (cases)			0.618
No	26	27
Yes	8	8
Tumor volume (cm³)			0.242
Range	3–146	7–116
Median	28	29
Initial treatment modality (cases)			0.543
Radiochemotherapy	11	9
Radiotherapy alone	23	26
Initial irradiation technique (cases)			0.218
2D	34	32
3D-CRT	0	2
IMRT	0	1

WHO World Health Organization, 2D two-dimension conventional radiotherapy, 3D-CRT three-dimension conformal radiotherapy, IMRT intensity-modulated radiotherapy, CCRT concomitant chemoradiotherapy, RT radiotherapy alone
^aBy χ² test
^bRestage according to the 2002 6th edition TNM staging system of the American Joint Commission on Cancer (AJCC)
^cPre-treatment serious complications include trismus, radiation encephalopathy, and posterior cranial nerve palsies

ISSN: 2523-3548