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Table 1 Summary of co-infection of EBV and HPV in several malignancies

From: Co-infection of Epstein-Barr virus and human papillomavirus in human tumorigenesis

Tumor type

Co-infection

Subtype of HPV

EBV product(s)

Reference

NPC

15% (Iran)

6/11, 16/18

EBER

[30]

 

34% (Morocco)

16, 31, 45, 48

EBER

[31]

 

42% (China)

18

EBER

[32]

Cervical cancer

31.8%

16, 18, 58

EBER

[39]

 

12.5%–69%

16, 18

BALF1, BARF-1, LMP1

[59]

 

21.2%–64.3%

16, 18

EBNA3B

[60]

Breast cancer

35%

16, 18, 33

LMP1, EBNA-1

[21]

Prostate cancer

8.8% (Sweden)

18

EBER

[88]

 

37% (United States)

18

EBER, EBNA-1

[89]

  1. EBV Epstein-Barr virus; HPV human papillomavirus; NPC nasopharyngeal carcinoma; EBER EBV-encoded RNA; BALF1 BamH1 A fragment leftward reading frame 1; BARF-1 BamH1-A right frame 1; LMP1 latent membrane protein 1; EBNA3B EBV nuclear antigen 3B; EBNA-1 EBV nuclear antigen