A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma

Table 5 The frequencies of RPMS1 SNP G155391A in NPC cases and healthy controls from various world regions

Sample	Source	Region	No. (sum)	G155391A			Frequency of G155391A (%)	NPC incidence	P*
Sample	Source	Region	No. (sum)	G	G/A	A	Frequency of G155391A (%)	NPC incidence	P*
NPC	TB	Shandong	36	23	0	13	36.1	Low
		Guangdong	122	22	0	100	82.0	High
		Hong Kong	30	2	0	28	93.3	High
		Singapore	30	9	0	21	70.0	High	<0.001
	TW	Shandong	22	17	0	5	22.7	Low
		Guangdong	1051	155	24	872	83.0	High	<0.001
Healthy subjects	TW	Europe	11	11	0	0	0.0	Low
		Henan	83	81	1	1	1.2	Low
		Beijing	100	91	1	8	8.0	Low
		Shanxi	116	109	1	6	5.2	Low
		Shandong	612	560	18	34	5.6	Low
		Guangdong	1440	614	129	697	48.4	High	<0.001

TB tumor biopsy. Other abbreviations as in Tables 1 and 2
* Data combined in regions with low/high NPC incidence and probability calculated by Fisher’s exact test

ISSN: 2523-3548