From: Expert consensus on maintenance treatment for metastatic colorectal cancer in China
Chemotherapy protocol | Route and cycles of administration |
---|---|
FOLFOX (mFOLFOX6)a,b | Oxaliplatin 85 mg/m2, intravenous infusion (IV) for 2 h on Day 1; leucovorin (LV) 400 mg/m2, IV for 2 h on Day 1; 5-fluorouracil (5-FU) 400 mg/m2, IV on Day 1, and then 1200 mg/m2 continuous IV for 2 days (total dose 2400 mg/m2 for 46–48 h) Protocol repeated every 2 weeks |
CapeOxa | Oxaliplatin 130 mg/m2, IV for >2 h on Day 1; capecitabine 850–1000 mg/m2, oral administration twice daily on Days 1–14, and then discontinued for 7 days Protocol repeated every 3 weeks |
FOLFIRIa,b | Irinotecan 180 mg/m2, IV > 30–90 min on Day 1; LV 400 mg/m2, IV for 2 h with irinotecan on Day 1; 5-FU 400 mg/m2, IV on Day 1 and then 1200 mg/m2/d continuous IV for 2 days (total dose 2400 mg/m2 for 46–48 h) Protocol repeated every 2 weeks |
FOLFOXIRIa | Irinotecan 165 mg/m2, oxaliplatin 85 mg/m2 plus LV 400 mg/m2, IV on Day 1; 5-FU 1600 mg/m2 per day, continuous IV for 2 days (total dose 3200 mg/m2 for 48 h) Protocol repeated every 2 weeks |