From: Molecular pathogenesis of sporadic colorectal cancers
Pathway
Frequency of genetic changes leading to deregulation
Non-hypermutated (%)
Hypermutated (%)
WNT signaling
92
97
TGF-β signaling
27
87
PI3K signaling
50
53
RTK-RAS signaling
59
80
TP53 signaling
64
47