SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients

Cancer Communications

Table 2 Meta-analysis of the association between SHMT1 C1420T polymorphism and non-Hodgkin lymphoma (NHL) risk

Variable	Number of studies	Cases/controls	T vs. C			TT vs. CC			CT+TT vs. CC			CT vs. CC			TT vs. CC+CT
Variable	Number of studies	Cases/controls	OR (95% CI)^a	P	P _het	OR (95% CI)^a	P	P _het	OR (95% CI)^a	P	P _het	OR (95% CI)^a	P	P _het	OR (95% CI)^b	P	P _het
All	8	3232/4077	1.09 (1.01–1.17)	0.025	0.293	1.18 (1.00–1.39)	0.046	0.072	1.10 (1.00–1.21)	0.054	0.652	1.08 (0.98–1.19)	0.140	0.640	1.19 (0.94–1.50)	0.144	0.035
Ethnicity
Caucasian	6	2043/2931	1.06 (0.97–1.16)	0.174	0.182	1.15 (0.95–1.39)	0.156	0.057	1.06 (0.94–1.19)	0.332	0.561	1.04 (0.92–1.17)	0.574	0.647	1.19 (0.88–1.60)	0.252	0.033
Mixed	2	1189/1146	1.13 (1.00–1.28)	0.051	0.620	1.25 (0.93–1.69)	0.141	0.149	1.18 (1.00–1.39)	0.050	0.784	1.16 (0.98–1.38)	0.081	0.423	1.21 (0.73–2.01)	0.458	0.087
Subtype
DLBCL	4	744/2353	0.96 (0.85–1.09)	0.555	0.357	0.95 (0.72–1.27)	0.744	0.319	0.94 (0.80–1.11)	0.490	0.562	0.94 (0.79–1.12)	0.490	0.717	0.98 (0.75–1.29)	0.895	0.370
FL	5	778/2558	1.05 (0.93–1.19)	0.454	0.292	1.04 (0.78–1.38)	0.804	0.208	1.09 (0.93–1.29)	0.343	0.298	1.10 (0.93–1.31)	0.263	0.297	0.99 (0.75–1.29)	0.926	0.156
Publication bias^c			0.829			0.389			0.290			0.024			0.234

The results were in italics, if the 95% CI excluded 1 or P < 0.05
P _het value of the Q test for heterogeneity
DLBCL diffuse large B-cell lymphoma, FL follicular lymphoma, OR, odds ratio, CI confidence interval
^aFixed-effects model
^bRandom-effects model
^c P value of the Egger test for publication bias

ISSN: 2523-3548