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Table 2 Meta-analysis of the association between SHMT1 C1420T polymorphism and non-Hodgkin lymphoma (NHL) risk

From: SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients

Variable Number of studies Cases/controls T vs. C TT vs. CC CT+TT vs. CC CT vs. CC TT vs. CC+CT
OR (95% CI)a P P het OR (95% CI)a P P het OR (95% CI)a P P het OR (95% CI)a P P het OR (95% CI)b P P het
All 8 3232/4077 1.09 (1.011.17) 0.025 0.293 1.18 (1.001.39) 0.046 0.072 1.10 (1.001.21) 0.054 0.652 1.08 (0.98–1.19) 0.140 0.640 1.19 (0.94–1.50) 0.144 0.035
Ethnicity                  
 Caucasian 6 2043/2931 1.06 (0.97–1.16) 0.174 0.182 1.15 (0.95–1.39) 0.156 0.057 1.06 (0.94–1.19) 0.332 0.561 1.04 (0.92–1.17) 0.574 0.647 1.19 (0.88–1.60) 0.252 0.033
 Mixed 2 1189/1146 1.13 (1.001.28) 0.051 0.620 1.25 (0.93–1.69) 0.141 0.149 1.18 (1.001.39) 0.050 0.784 1.16 (0.98–1.38) 0.081 0.423 1.21 (0.73–2.01) 0.458 0.087
Subtype                  
 DLBCL 4 744/2353 0.96 (0.85–1.09) 0.555 0.357 0.95 (0.72–1.27) 0.744 0.319 0.94 (0.80–1.11) 0.490 0.562 0.94 (0.79–1.12) 0.490 0.717 0.98 (0.75–1.29) 0.895 0.370
 FL 5 778/2558 1.05 (0.93–1.19) 0.454 0.292 1.04 (0.78–1.38) 0.804 0.208 1.09 (0.93–1.29) 0.343 0.298 1.10 (0.93–1.31) 0.263 0.297 0.99 (0.75–1.29) 0.926 0.156
Publication biasc   0.829 0.389 0.290 0.024 0.234
  1. The results were in italics, if the 95% CI excluded 1 or P < 0.05
  2. P het value of the Q test for heterogeneity
  3. DLBCL diffuse large B-cell lymphoma, FL follicular lymphoma, OR, odds ratio, CI confidence interval
  4. aFixed-effects model
  5. bRandom-effects model
  6. c P value of the Egger test for publication bias