Table 3 Univariate and multivariate analyses of variables associated with overall survival of patients with newly diagnosed metastatic colorectal cancer

Gender

0.055

0.07

 Male

1 (reference)

1 (reference)

 Female

0.804 (0.644–1.004)

0.812 (0.648-1.017)

Age (years)

0.567

0.199

 <65

1 (reference)

1 (reference)

 ≥65

1.070 (0.849–1.347)

0.842 (0.647–1.095)

ECOG performance status

0.005

<0.001

 <2

1 (reference)

1 (reference)

 ≥2

1.388 (1.103–1.747)

1.620 (1.244–2.111)

Site of primary tumor

0.974

0.938

 Colon

1 (reference)

1 (reference)

 Rectum

1.004 (0.806–1.250)

1.009 (0.809–1.257)

No. of metastatic sites

0.002

0.065

 ≤2

1 (reference)

1 (reference)

 >2

1.417 (1.135–1.769)

1.252 (0.986–1.589)

Tumor differentiation

<0.001

0.002

 Well or moderate

1 (reference)

1 (reference)

 Poor

1.736 (1.385–2.176)

1.484 (1.159–1.901)

Pre-chemotherapy ALC (×10⁹/L)

0.121

0.391

 <2.70

1 (reference)

1 (reference)

 ≥2.70

0.841 (0.676–1.047)

0.884 (0.668–1.171)

Pre-chemotherapy AMC (×10⁹/L)

<0.001

<0.001

 <0.55

1 (reference)

1 (reference)

 ≥0.55

1.514 (1.204–1.903)

1.703 (1263–2.296)

Pre-chemotherapy LMR

<0.001

0.004

 <3.11

1 (reference)

1 (reference)

 ≥3.11

0.568 (0.453–0.712)

0.662 (0.501–0.875)