Advertisement
Table 3 Univariate and multivariate analyses of variables associated with overall survival of patients with newly diagnosed metastatic colorectal cancer
| Characteristic | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender | 0.055 | 0.07 | ||
| Male | 1 (reference) | 1 (reference) | ||
| Female | 0.804 (0.644–1.004) | 0.812 (0.648-1.017) | ||
| Age (years) | 0.567 | 0.199 | ||
| <65 | 1 (reference) | 1 (reference) | ||
| ≥65 | 1.070 (0.849–1.347) | 0.842 (0.647–1.095) | ||
| ECOG performance status | 0.005 | <0.001 | ||
| <2 | 1 (reference) | 1 (reference) | ||
| ≥2 | 1.388 (1.103–1.747) | 1.620 (1.244–2.111) | ||
| Site of primary tumor | 0.974 | 0.938 | ||
| Colon | 1 (reference) | 1 (reference) | ||
| Rectum | 1.004 (0.806–1.250) | 1.009 (0.809–1.257) | ||
| No. of metastatic sites | 0.002 | 0.065 | ||
| ≤2 | 1 (reference) | 1 (reference) | ||
| >2 | 1.417 (1.135–1.769) | 1.252 (0.986–1.589) | ||
| Tumor differentiation | <0.001 | 0.002 | ||
| Well or moderate | 1 (reference) | 1 (reference) | ||
| Poor | 1.736 (1.385–2.176) | 1.484 (1.159–1.901) | ||
| Pre-chemotherapy ALC (×109/L) | 0.121 | 0.391 | ||
| <2.70 | 1 (reference) | 1 (reference) | ||
| ≥2.70 | 0.841 (0.676–1.047) | 0.884 (0.668–1.171) | ||
| Pre-chemotherapy AMC (×109/L) | <0.001 | <0.001 | ||
| <0.55 | 1 (reference) | 1 (reference) | ||
| ≥0.55 | 1.514 (1.204–1.903) | 1.703 (1263–2.296) | ||
| Pre-chemotherapy LMR | <0.001 | 0.004 | ||
| <3.11 | 1 (reference) | 1 (reference) | ||
| ≥3.11 | 0.568 (0.453–0.712) | 0.662 (0.501–0.875) | ||
