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Table 2 Univariate Cox regression analysis for survival of ESCC patients

From: Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy

Variable

Overall survival

Disease-free survival

HR (95% CI)

P value

HR (95% CI)

P value

Sex

 

0.846

 

0.576

 Females

1

 

1

 

 Males

0.96 (0.60–1.52)

 

1.14 (0.72–1.79)

 

Age (years)

 

<0.001

 

<0.001

 ≤59

1

 

1

 

 >59

2.48 (1.73–3.57)

 

1.81 (1.30–2.52)

 

Tumor location

 

0.338

 

0.141

 Upper-thoracic esophagus

1

 

1

 

 Middle-thoracic esophagus

1.51 (0.73–3.13)

 

1.72 (0.87–3.41)

0.119

 Lower-thoracic esophagus

1.20 (0.55–2.60)

 

1.30 (0.63–2.70)

0.479

Tumor size (cm)

 

0.291

 

0.276

 <4

1

 

1

 

 ≥4

1.21 (0.85–1.72)

 

1.20 (0.86–1.67)

 

Pathologic grade

 

0.423

 

0.534

 I/II

1

 

1

 

 III

1.17 (0.80–1.69)

 

1.12 (0.78–1.59)

 

TNM stage

 

<0.001

 

<0.001

 I–IIA

1

 

1

 

 IIB–IV

3.16 (2.07–4.83)

 

3.24 (2.19–4.80)

 

T category

 

0.018

 

0.051

 1 + 2

1

 

1

 

 3 + 4

1.89 (1.12–3.21)

 

1.59 (0.99–2.52)

 

N category

 

<0.001

 

<0.001

 0

1

 

1

 

 1

2.97 (1.97–4.47)

 

3.12 (2.13–4.57)

 

HBsAg

 

0.199

 

0.802

 Negative

1

 

1

 

 Positive

0.584 (0.26–1.33)

 

1.08 (0.58–2.00)

 

Family historya

 

0.486

 

0.271

 No

1

 

1

 

 Yes

0.79 (0.40–1.55)

 

0.70 (0.37–1.33)

 

Glasgow prognostic score

 

0.033

 

0.169

 0

1

 

1

 

 1

0.99 (0.60–1.62)

0.951

0.89 (0.56–1.43)

0.633

 2

14.70 (1.95–110.58)

0.008

6.26 (0.86–45.63)

0.070

DA score

 

<0.001

 

<0.001

 0

1

 

1

 

 1

2.50 (1.37–4.59)

0.003

1.94 (1.15–3.27)

0.013

 2

4.12 (2.25–7.54)

<0.001

2.99 (1.77–5.08)

<0.001

  1. HR hazard ratio, CI confidence interval; other abbreviations as in Table1
  2. aPatients whose first-grade relatives have a history of esophageal cancer