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Table 2 Univariate Cox regression analysis for survival of ESCC patients

From: Cumulative scores based on plasma D-dimer and serum albumin levels predict survival in esophageal squamous cell carcinoma patients treated with transthoracic esophagectomy

Variable Overall survival Disease-free survival
HR (95% CI) P value HR (95% CI) P value
Sex   0.846   0.576
 Females 1   1  
 Males 0.96 (0.60–1.52)   1.14 (0.72–1.79)  
Age (years)   <0.001   <0.001
 ≤59 1   1  
 >59 2.48 (1.73–3.57)   1.81 (1.30–2.52)  
Tumor location   0.338   0.141
 Upper-thoracic esophagus 1   1  
 Middle-thoracic esophagus 1.51 (0.73–3.13)   1.72 (0.87–3.41) 0.119
 Lower-thoracic esophagus 1.20 (0.55–2.60)   1.30 (0.63–2.70) 0.479
Tumor size (cm)   0.291   0.276
 <4 1   1  
 ≥4 1.21 (0.85–1.72)   1.20 (0.86–1.67)  
Pathologic grade   0.423   0.534
 I/II 1   1  
 III 1.17 (0.80–1.69)   1.12 (0.78–1.59)  
TNM stage   <0.001   <0.001
 I–IIA 1   1  
 IIB–IV 3.16 (2.07–4.83)   3.24 (2.19–4.80)  
T category   0.018   0.051
 1 + 2 1   1  
 3 + 4 1.89 (1.12–3.21)   1.59 (0.99–2.52)  
N category   <0.001   <0.001
 0 1   1  
 1 2.97 (1.97–4.47)   3.12 (2.13–4.57)  
HBsAg   0.199   0.802
 Negative 1   1  
 Positive 0.584 (0.26–1.33)   1.08 (0.58–2.00)  
Family historya   0.486   0.271
 No 1   1  
 Yes 0.79 (0.40–1.55)   0.70 (0.37–1.33)  
Glasgow prognostic score   0.033   0.169
 0 1   1  
 1 0.99 (0.60–1.62) 0.951 0.89 (0.56–1.43) 0.633
 2 14.70 (1.95–110.58) 0.008 6.26 (0.86–45.63) 0.070
DA score   <0.001   <0.001
 0 1   1  
 1 2.50 (1.37–4.59) 0.003 1.94 (1.15–3.27) 0.013
 2 4.12 (2.25–7.54) <0.001 2.99 (1.77–5.08) <0.001
  1. HR hazard ratio, CI confidence interval; other abbreviations as in Table1
  2. aPatients whose first-grade relatives have a history of esophageal cancer