Table 3 The adverse events in the 40 Chinese patients with mCRC treated with the SOL regimen
Event | NCI-CTCAE grade, version 3.0 [cases (%)] | ||
|---|---|---|---|
1 | 2 | 3 | |
Leukopenia | 7 (17.5) | 7 (17.5) | 0 |
Neutropenia | 6 (15.0) | 4 (10.0) | 1 (2.5) |
Anemia | 3 (7.5) | 3 (7.5) | 0 |
Thrombocytopenia | 5 (12.5) | 7 (17.5) | 3 (7.5) |
Anorexia | 19 (47.5) | 8 (20.0) | 0 |
Nausea | 16 (40.0) | 6 (15.0) | 3 (7.5) |
Vomiting | 6 (15.0) | 6 (15.0) | 3 (7.5) |
Diarrhea | 5 (12.5) | 9 (22.5) | 8 (20.0) |
Stomatitis | 4 (10.0) | 2 (5.0) | 1 (2.5) |
Constipation | 4 (10.0) | 0 | 0 |
Fatigue | 18 (45.0) | 5 (12.5) | 1 (2.5) |
Alopecia | 29 (72.5) | 6 (15.0) | 0 |
Pigmentation | 5 (12.5) | 14 (35.0) | 0 |
Hand-foot syndrome | 14 (35.0) | 2 (5.0) | 1 (2.5) |
Neuropathy | 21 (52.5) | 12 (30.0) | 5 (12.5) |
Abnormal ALT/AST | 7 (17.5) | 3 (7.5) | 1 (2.5) |