Fig. 2
From: Differentiation therapy: a promising strategy for cancer treatment
Restoring IkB kinase α (IKKα) promotes nasopharyngeal carcinoma differentiation. In undifferentiated NPC cells, IKKα is epigenetically suppressed by enhancer of zeste homologue 2 (EZH2) (left). After ATRA treatment, IKKα is restored, and the tumor cells differentiate towards normal cells (right). EED, embryonic ectoderm development; SUZ12, suppressor of zeste 12