From: Structural analysis of tumor-related single amino acid mutations in human MxA protein
Mutation influence | Position in protein | Polarity before mutation | Polarity after mutation |
---|---|---|---|
Drastic mutations | |||
 L95P | Buried | Nonpolar | Special |
 P96S | Exposed | Special | Polar |
 G392V | Exposed | Special | Nonpolar |
 V449G | Buried | Nonpolar | Special |
 P218S | Exposed | Special | Polar |
 R522C | Exposed | Positively charged | Weak polar |
 E632K | Buried | Negatively charged | Positively charged |
Moderate mutations | |||
 V263M | Buried | Nonpolar | Nonpolar |
 K326N | Exposed | Positively charged | Polar |
 R649W | Exposed | Positively charged | Nonpolar |
 T651M | Exposed | Polar | Nonpolar |
 T654Q | Buried | Polar | Polar |
 R655C | Exposed | Positively charged | Weak polar |
Very moderate mutations | |||
 S134L | Exposed | Polar | Nonpolar |
 R310S | Exposed | Positively charged | Polar |
 N491K | Exposed | Polar | Positively charged |
 L619I | Buried | Nonpolar | Nonpolar |
 L634V | Exposed | Nonpolar | Nonpolar |
Unpredictable mutations | |||
 T27S | Exposed | Polar | Polar |
 Y538C | Exposed | Polar | Weak polar |
 G540D | Exposed | Special | Negatively charged |
 S572Y | Exposed | Polar | Polar |