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Table 3 Summary of the structural analysis of cancer-related MxA single-point mutations

From: Structural analysis of tumor-related single amino acid mutations in human MxA protein

Mutation influence Position in protein Polarity before mutation Polarity after mutation
Drastic mutations
 L95P Buried Nonpolar Special
 P96S Exposed Special Polar
 G392V Exposed Special Nonpolar
 V449G Buried Nonpolar Special
 P218S Exposed Special Polar
 R522C Exposed Positively charged Weak polar
 E632K Buried Negatively charged Positively charged
Moderate mutations
 V263M Buried Nonpolar Nonpolar
 K326N Exposed Positively charged Polar
 R649W Exposed Positively charged Nonpolar
 T651M Exposed Polar Nonpolar
 T654Q Buried Polar Polar
 R655C Exposed Positively charged Weak polar
Very moderate mutations
 S134L Exposed Polar Nonpolar
 R310S Exposed Positively charged Polar
 N491K Exposed Polar Positively charged
 L619I Buried Nonpolar Nonpolar
 L634V Exposed Nonpolar Nonpolar
Unpredictable mutations
 T27S Exposed Polar Polar
 Y538C Exposed Polar Weak polar
 G540D Exposed Special Negatively charged
 S572Y Exposed Polar Polar