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Table 3 Summary of the structural analysis of cancer-related MxA single-point mutations

From: Structural analysis of tumor-related single amino acid mutations in human MxA protein

Mutation influence

Position in protein

Polarity before mutation

Polarity after mutation

Drastic mutations

 L95P

Buried

Nonpolar

Special

 P96S

Exposed

Special

Polar

 G392V

Exposed

Special

Nonpolar

 V449G

Buried

Nonpolar

Special

 P218S

Exposed

Special

Polar

 R522C

Exposed

Positively charged

Weak polar

 E632K

Buried

Negatively charged

Positively charged

Moderate mutations

 V263M

Buried

Nonpolar

Nonpolar

 K326N

Exposed

Positively charged

Polar

 R649W

Exposed

Positively charged

Nonpolar

 T651M

Exposed

Polar

Nonpolar

 T654Q

Buried

Polar

Polar

 R655C

Exposed

Positively charged

Weak polar

Very moderate mutations

 S134L

Exposed

Polar

Nonpolar

 R310S

Exposed

Positively charged

Polar

 N491K

Exposed

Polar

Positively charged

 L619I

Buried

Nonpolar

Nonpolar

 L634V

Exposed

Nonpolar

Nonpolar

Unpredictable mutations

 T27S

Exposed

Polar

Polar

 Y538C

Exposed

Polar

Weak polar

 G540D

Exposed

Special

Negatively charged

 S572Y

Exposed

Polar

Polar