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Table 1 Potential inhibitors of Wnt3a

From: Wnt3a: functions and implications in cancer

Tissue type Cell line(s) Potential inhibitor(s) of Wnt3a Reference(s)
Breast cancer EpRas
MDA-MB-231, T-47D
MDA-MB-231
MCF-7
Knockdown of MARCKS-related protein
Niclosamide and silibinin
Kallistatin
Deep-sea water
β-estradiol
Knockdown of FAK protein
[88]
[111, 112]
[99]
[114]
[49]
[95]
Colon cancer SW480 MEK inhibitor PD98059, genistein, and wortmannin [100]
Gastric cancer Gastric cancer cells Receptor for activated protein kinase C [103]
Leukemia U937 Cordycepin [107]
Liver cancer Huh-7 Variant 3 of collagen XVIII
HS20
[89]
[96]
Multiple myeloma OPM-2, and MM patients’ plasma cells DKK1 [92]
Melanoma A375 and A2058 Loss of FAM129B [94]
Prostate cancer C4-2B
PC-3 and DU145
Axin
Niclosamide and silibinin
[79]
[111, 112]
Renal carcinoma ACHN Enhancer of zeste homolog 2 small interfering RNA [93]
Teratocarcinoma F9
NT2
RGS19
All-trans-retinoic acid
[104]
[115]
HEK293 HEK293 Etinoic acid
Variant 3 of collagen XVIII
Purified recombinant frizzled cysteine-rich domain
MEK inhibitor PD98059, genistein, and wortmannin
Aspirin and norcantharidin
Hexachlorophene
Demethoxycurcumin and bisdemethoxycurcumin
Mesd C-terminal region peptide and full-length Mesd protein
A diterpenoid derivative, 15-oxospiramilactone
Niclosamide and silibinin
Magnolo l
[49]
[89]
[98]
[100]
[108]
[109]
[110]
[105]
[106]
[111, 112]
[116]
Embryos Cytotrophoblasts
Neural plate
DKK1
Knockdown of FAK
[15]
[95]
B lymphopoiesis CD133+CD10CD10+ cells DKK1 [30]
Fibroblasts NIH3T3 Chondroitin sulfate-E [97]
Osteoblasts
Osteoblast-like cells
Osteoblasts
Saos-2, MG63, C2C12, and hFOB1.19
C2C12
DKK1
DKK1
Mesd C-terminal region peptide
[90]
[91, 92]
[105]
  1. MARCKS myristoylated alanine-rich C-kinase substrate, FAK focal adhesion kinase, MEK mitogen activated and extracellular regulated kinase, HS20 a human monoclonal antibody against GPC3, GPC3 glypican-3, DKK1 Dickkopf-related protein 1, FAM129B family with sequence similarity 129, member B, RGS19 regulator of G-protein signaling 19