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Table 1 Potential inhibitors of Wnt3a

From: Wnt3a: functions and implications in cancer

Tissue type

Cell line(s)

Potential inhibitor(s) of Wnt3a

Reference(s)

Breast cancer

EpRas

MDA-MB-231, T-47D

MDA-MB-231

MCF-7

Knockdown of MARCKS-related protein

Niclosamide and silibinin

Kallistatin

Deep-sea water

β-estradiol

Knockdown of FAK protein

[88]

[111, 112]

[99]

[114]

[49]

[95]

Colon cancer

SW480

MEK inhibitor PD98059, genistein, and wortmannin

[100]

Gastric cancer

Gastric cancer cells

Receptor for activated protein kinase C

[103]

Leukemia

U937

Cordycepin

[107]

Liver cancer

Huh-7

Variant 3 of collagen XVIII

HS20

[89]

[96]

Multiple myeloma

OPM-2, and MM patients’ plasma cells

DKK1

[92]

Melanoma

A375 and A2058

Loss of FAM129B

[94]

Prostate cancer

C4-2B

PC-3 and DU145

Axin

Niclosamide and silibinin

[79]

[111, 112]

Renal carcinoma

ACHN

Enhancer of zeste homolog 2 small interfering RNA

[93]

Teratocarcinoma

F9

NT2

RGS19

All-trans-retinoic acid

[104]

[115]

HEK293

HEK293

Etinoic acid

Variant 3 of collagen XVIII

Purified recombinant frizzled cysteine-rich domain

MEK inhibitor PD98059, genistein, and wortmannin

Aspirin and norcantharidin

Hexachlorophene

Demethoxycurcumin and bisdemethoxycurcumin

Mesd C-terminal region peptide and full-length Mesd protein

A diterpenoid derivative, 15-oxospiramilactone

Niclosamide and silibinin

Magnolo l

[49]

[89]

[98]

[100]

[108]

[109]

[110]

[105]

[106]

[111, 112]

[116]

Embryos

Cytotrophoblasts

Neural plate

DKK1

Knockdown of FAK

[15]

[95]

B lymphopoiesis

CD133+CD10−CD10+ cells

DKK1

[30]

Fibroblasts

NIH3T3

Chondroitin sulfate-E

[97]

Osteoblasts

Osteoblast-like cells

Osteoblasts

Saos-2, MG63, C2C12, and hFOB1.19

C2C12

DKK1

DKK1

Mesd C-terminal region peptide

[90]

[91, 92]

[105]

  1. MARCKS myristoylated alanine-rich C-kinase substrate, FAK focal adhesion kinase, MEK mitogen activated and extracellular regulated kinase, HS20 a human monoclonal antibody against GPC3, GPC3 glypican-3, DKK1 Dickkopf-related protein 1, FAM129B family with sequence similarity 129, member B, RGS19 regulator of G-protein signaling 19