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Table 1 Mapping from hallmarks to Gene ontology (GO) processes

From: A multilevel pan-cancer map links gene mutations to cancer hallmarks

Hallmark No. of genes No. of pathways Linked GO processes and function
Sustaining proliferative signaling 343 50 GO:0008283, cell proliferation
GO:0016049, cell growth
GO:0007049, cell cycle
GO:0051301, cell division
GO:0008284, positive regulation of cell proliferation
GO:0030307, positive regulation of cell growth
GO:0045787, positive regulation of cell cycle
GO:0051781, positive regulation of cell division
Evading growth suppressors 182 13 GO:0009968, negative regulation of signal transduction
GO:0008285, negative regulation of cell proliferation
GO:0030308, negative regulation of cell growth
GO:0045786, negative regulation of cell cycle
GO:0051782, negative regulation of cell division
Resisting cell death 404 57 GO:0012501, programmed cell death
GO:0043067, regulation of programmed cell death
Replicative immortality 2 1 GO:0090398, cellular senescence
GO:0032200, telomere organization
GO:0000723, telomere maintenance
GO:0032204, regulation of telomere maintenance
GO:0001302, replicative cell aging
GO:1900062, regulation of replicative cell aging
GO:2000772, regulation of cellular senescence
Sustained angiogenesis 105 12 GO:0001525, angiogenesis
GO:0045765, regulation of angiogenesis
GO:0001570, vasculogenesis
GO:2001212, regulation of vasculogenesis
GO:0008015, blood circulation
Tissue invasion and metastasis 614 82 GO:0007155, cell adhesion
GO:0001837, epithelial-to-mesenchymal transition
GO:0016477, cell migration
GO:0030155, regulation of cell adhesion
GO:0030030, cell projection organization
GO:0030036, actin cytoskeleton organization
GO:0030030, cell projection organization
GO:0034330, cell junction organization
GO:0042330, taxis
GO:0007163, establishment or maintenance of cell polarity
Genome instability 124 7 GO:0006281, DNA repair
GO:0031570, DNA integrity checkpoint
GO:0045005, maintenance of fidelity involved in DNA-dependent DNA replication
GO:0006282, regulation of DNA repair
Tumor-promoting inflammation 84 9 GO:0006954, inflammatory response
GO:0002367, cytokine production involved in immune response
GO:0002718, regulation of cytokine production involved in immune response
GO:0042060, wound healing
GO:0061041, regulation of wound healing
GO:0050727, regulation of inflammatory response
GO:0042533, tumor necrosis factor biosynthetic process
Reprogramming energy metabolism 8 2 GO:0006006, glucose metabolic process
GO:0046323, glucose import
GO:0006096, glycolysis
GO:0071456, cellular response to hypoxia
Evading immune destruction 150 19 GO:0006955, immune response
GO:0002418, immune response to tumor cells
GO:0002837, regulation of immune response to tumor cells
GO:0020012, evasion or tolerance of host immune response
GO:0006897, endocytosis
Other 1047 142