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Fig. 4 | Chinese Journal of Cancer

Fig. 4

From: A multilevel pan-cancer map links gene mutations to cancer hallmarks

Fig. 4

Infrequently mutated genes are part of ME and CO associations. a Mutations (depicted in black) in 6 genes that exhibited significant ME and CO associations in 296 HNSC samples. Genes with an asterisk are significantly frequently mutated (SFM). Numbers in parentheses behind the genes indicate the number of mutations. The blue and red lines to the right link ME and CO pairs, respectively. Numbers to the right of lines indicate the observed overlap (number of samples that have a mutation in both genes) followed by the randomly expected overlap. b Bar diagram similar to Fig. 3a, where CO and ME associations are divided into three groups: (1) both SFM, where both members of the pair are SFM; (2) one SFM, where one member is SFM; and (3) none SFM, where neither is SFM. CASP8, caspase 8; EP300, E1A-binding protein p300. Other abbreviations as in Figs. 2 and 3

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