Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis

Cancer Communications

Table 2 Genes up-regulated or down-regulated at least 1.5-fold by overexpression of CYB5R2 in HONE1 cells

Pathway	Gene symbol	Name of gene	Fold change in expression
Apoptosis and cell senescence	FAS	Fas (tumor necrosis factor receptor superfamily member 6)	1.81
Signal transduction and transcription	FOS	FBJ murine osteosarcoma viral oncogene homolog	1.86
Signal transduction and transcription	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1 (alpha)	1.57
Adhesion	ITGB3	Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61)	1.68
	MTSS1	Metastasis suppressor 1	1.59
	ITGB5	Integrin beta 5	−8.72
Angiogenesis	IFNB1	Interferon beta 1, fibroblast	1.84
	VEGFA	Vascular endothelial growth factor A	−1.69
	IGF1	Insulin-like growth factor 1 (somatomedin C)	−1.57
	TEK	TEK tyrosine kinase, endothelial	−10.28
	TGFBR1	Transforming growth factor beta receptor 1	−1.71
Cell cycle control and DNA damage repair	CDKN2A	Cyclin-dependent kinase inhibitor 2A	1.57

ISSN: 2523-3548