Skip to main content

Advertisement

Table 5 Univariate and Multivariate Cox regression analysis of potential prognostic factors for 464 lung cancer patients

From: The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer

Variable Univariate model Multivariate model
HR 95% CI P HR 95% CI P
Age    
 <60 years 1.000      
 ≥60 years 1.151 0.926–1.432 0.206    
Sex    
 Female 1.000      
 Male 1.285 0.997–1.657 0.053    
Smoking status       
 No 1.000    1.000   
 Yes 1.533 1.224–1.919 <0.001 1.462 1.080–1.980 0.014
Treatment       
 Multimodality therapy without operation 1.000    1.000   
 Operation alone 0.231 0.173–0.309 <0.001 0.568 0.367–0.880 0.011
 Operation and multimodality therapy 0.326 0.250–0.425 <0.001 0.492 0.362–0.669 <0.001
T stage       
 T1 1.000    1.000   
 T2 1.176 0.820–1.686 0.378 1.081 0.753–1.552 0.671
 T3 2.019 1.382–2.951 <0.001 1.352 0.920–1.987 0.124
 T4 2.162 1.436–3.253 <0.001 1.013 0.668–1.536 0.951
N stage       
 N0 1.000    1.000   
 N1 1.043 0.730–1.489 0.817 0.789 0.549–1.133 0.199
 N2 1.756 1.346–2.293 <0.001 0.797 0.599–1.058 0.117
 N3 2.725 1.958–3.793 <0.001 1.155 0.816–1.636 0.416
M stage       
 M0 1.000    1.000   
 M1 3.091 2.448–3.902 <0.001 0.985 0.681–1.424 0.936
Clinical stage       
 I 1.000    1.000   
 II 3.742 2.213–6.325 <0.001 3.254 1.909–5.546 <0.001
 III 5.267 3.239–8.563 <0.001 3.435 2.013–5.864 <0.001
 IV 11.25 6.855–18.461 <0.001 5.685 3.063–10.549 <0.001
CRP-SAA       
 Low level 1.000    1.000   
 High level 2.097 1.673–2.628 <0.001 1.545 1.223–1.951 <0.001
Total SAA       
 Low level 1.000    1.000   
 High level 1.778 1.429–2.212 <0.001 1.329 1.061–1.663 0.013
CRP       
 Low level 1.000    1.000   
 High level 2.045 1.641–2.549 <0.001 1.454 1.156–1.829 0.001
  1. “−”, age and sex are not included in the Multivariate Cox regression analysis. Other footnotes as in Table 4.