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Table 2 Differentially expressed CRP-bound proteins in lung cancer patients identified by MALDI-TOF/TOF MS/MS

From: The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer

Protein name Spot no. Accession no. Molecular weight (Da) Protein PI Protein score (CI) Total ion score (CI) Best ion score (CI) Peptide count Intensity matched Fold change*
SAA1/SAA2 5,107 IPI00552578 13,523.5 6.28 284 (100%) 212 (100%) 96 (100%) 8 19.769 +∞
6,109 IPI00552578 13,523.5 6.28 279 (100%) 207 (100%) 98 (100%) 8 34.058 +∞
8,113 IPI00006146 13,518.6 9.20 338 (100%) 280 (100%) 102 (100%) 7 33.873 +∞
9,104 IPI00006146 13,518.6 9.20 143 (100%) 83 (100%) 62 (100%) 7 14.093 +∞
APOE 4,108 IPI00021842 36,131.8 5.65 105 (100%) 79 (100%) 38 (97.11%) 8 8.824 −10.32
7,114 IPI00021842 36,131.8 5.65 74 (99.67%) 35 (94.84%) 24 (31.61%) 11 7.507 +2.01
3,414 IPI00021842 36,131.8 5.65 187 (100%) 93 (100%) 36 (93.32%) 16 19.241 −2.53
KRT1 8,115 IPI00220327 65,978.0 8.16 132 (100%) 83 (100%) 43 (97.55%) 13 8.195 +2.46
3,217 IPI00220327 65,978.0 8.16 290 (100%) 197 (100%) 66 (99.99%) 18 22.338 +3.02
8,623 IPI00220327 65,978.0 8.16 64 (97.22%) 20 (0%) 11 (0%) 12 5.121 +2.11
CLUa 2,407 IPI00291262 52,461.0 5.89 331 (100%) 298 (100%) 69 (99.99%) 9 46.414 +2.06
CLUb 2,409 IPI00795633 52,332.0 5.97 338 (100%) 296 (100%) 91 (100%) 10 61.136 +2.02
HBA1/HBA2 7,410 IPI00410714 15,247.9 8.72 97 (99.99%) 82 (100%) 82 (99.69%) 3 16.458 +2.23
Actinc 3,514 IPI00922240 38,608.2 5.19 74 (99.69%) 29 (55.07%) 29 (0%) 9 5.190 +2.34
TTR 4,107 IPI00646384 13,146.4 5.34 83 (99.96%) 65 (99.99%) 65 (99.99%) 3 15.846 +2.04
VIM 7,617 IPI00418471 53,619.1 5.06 64 (96.58%) 21 (0%) 18 (0%) 13 36.297 +2.65
IGKC 8,312 IPI00430847 25,690.7 8.18 110 (100%) 83 (100%) 59 (99.98%) 5 4.978 +2.47
ENO1 8,620 IPI00465248 47,139.3 7.01 82 (99.96%) 19 (0%) 14 (0%) 12 16.301 +2.28
  1. CRP C-reactive protein, MALDI-TOF/TOF MS/MS matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometry/mass spectrometry, PI isoelectric point, CI confidence interval, SAA serum amyloid A, APOE apolipoprotein E, KRT1 keratin, type II cytoskeletal 1, CLU clusterin, HBA hemoglobin, TTR transthyretin, VIM vimentin, IGKC Ig kappa chain C region, ENO1 enolase 1.
  2. * Fold-change of the protein levels in serum samples from lung cancer patients to those in serum samples from healthy controls: “+∞” indicates tending to be infinity; “+” indicates up-regulation; “−” indicates down-regulation. SAA was only presented in serum samples from lung cancer patients but not in those from healthy controls, thus the fold-change tends to be infinity.
  3. aHighly similar to Clusterin.
  4. bcDNA FLJ57622, highly similar to Clusterin.
  5. ccDNA FLJ55253, highly similar to Actin, cytoplasmic 1.