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Table 2 Differentially expressed CRP-bound proteins in lung cancer patients identified by MALDI-TOF/TOF MS/MS

From: The prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer

Protein name

Spot no.

Accession no.

Molecular weight (Da)

Protein PI

Protein score (CI)

Total ion score (CI)

Best ion score (CI)

Peptide count

Intensity matched

Fold change*

SAA1/SAA2

5,107

IPI00552578

13,523.5

6.28

284 (100%)

212 (100%)

96 (100%)

8

19.769

+∞

6,109

IPI00552578

13,523.5

6.28

279 (100%)

207 (100%)

98 (100%)

8

34.058

+∞

8,113

IPI00006146

13,518.6

9.20

338 (100%)

280 (100%)

102 (100%)

7

33.873

+∞

9,104

IPI00006146

13,518.6

9.20

143 (100%)

83 (100%)

62 (100%)

7

14.093

+∞

APOE

4,108

IPI00021842

36,131.8

5.65

105 (100%)

79 (100%)

38 (97.11%)

8

8.824

−10.32

7,114

IPI00021842

36,131.8

5.65

74 (99.67%)

35 (94.84%)

24 (31.61%)

11

7.507

+2.01

3,414

IPI00021842

36,131.8

5.65

187 (100%)

93 (100%)

36 (93.32%)

16

19.241

−2.53

KRT1

8,115

IPI00220327

65,978.0

8.16

132 (100%)

83 (100%)

43 (97.55%)

13

8.195

+2.46

3,217

IPI00220327

65,978.0

8.16

290 (100%)

197 (100%)

66 (99.99%)

18

22.338

+3.02

8,623

IPI00220327

65,978.0

8.16

64 (97.22%)

20 (0%)

11 (0%)

12

5.121

+2.11

CLUa

2,407

IPI00291262

52,461.0

5.89

331 (100%)

298 (100%)

69 (99.99%)

9

46.414

+2.06

CLUb

2,409

IPI00795633

52,332.0

5.97

338 (100%)

296 (100%)

91 (100%)

10

61.136

+2.02

HBA1/HBA2

7,410

IPI00410714

15,247.9

8.72

97 (99.99%)

82 (100%)

82 (99.69%)

3

16.458

+2.23

Actinc

3,514

IPI00922240

38,608.2

5.19

74 (99.69%)

29 (55.07%)

29 (0%)

9

5.190

+2.34

TTR

4,107

IPI00646384

13,146.4

5.34

83 (99.96%)

65 (99.99%)

65 (99.99%)

3

15.846

+2.04

VIM

7,617

IPI00418471

53,619.1

5.06

64 (96.58%)

21 (0%)

18 (0%)

13

36.297

+2.65

IGKC

8,312

IPI00430847

25,690.7

8.18

110 (100%)

83 (100%)

59 (99.98%)

5

4.978

+2.47

ENO1

8,620

IPI00465248

47,139.3

7.01

82 (99.96%)

19 (0%)

14 (0%)

12

16.301

+2.28

  1. CRP C-reactive protein, MALDI-TOF/TOF MS/MS matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometry/mass spectrometry, PI isoelectric point, CI confidence interval, SAA serum amyloid A, APOE apolipoprotein E, KRT1 keratin, type II cytoskeletal 1, CLU clusterin, HBA hemoglobin, TTR transthyretin, VIM vimentin, IGKC Ig kappa chain C region, ENO1 enolase 1.
  2. * Fold-change of the protein levels in serum samples from lung cancer patients to those in serum samples from healthy controls: “+∞” indicates tending to be infinity; “+” indicates up-regulation; “−” indicates down-regulation. SAA was only presented in serum samples from lung cancer patients but not in those from healthy controls, thus the fold-change tends to be infinity.
  3. aHighly similar to Clusterin.
  4. bcDNA FLJ57622, highly similar to Clusterin.
  5. ccDNA FLJ55253, highly similar to Actin, cytoplasmic 1.