Skip to main content

Advertisement

Table 2 Comparison of the clinical characteristics between relapsed patients with and without brain metastasis

From: Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment

Variable Patients with brain metastasis Patients without brain metastasis P value
Total (cases) 11 44  
Age (years)
 Median 4 5 0.073
 Range 2–10 1–10
Sex (cases)
 Male 8 30 0.632
 Female 3 14
MYCN status (cases)a
 Positive 2 6 0.572
 Negative 5 11
Bone marrow involvement (cases)
 Yes 11 35 0.101
 No 0 9
Lactate dehydrogenaseb
 Median (U/L) 568 353 0.076
 Range (U/L) 197–3,906 188–3,903  
 0–500 U/L (cases) 6 23 0.533
 501–1,000 U/L (cases) 4 10  
 >1,000 U/L (cases) 1 9  
Tumor response (cases)
 CR 8 34 0.719
 PR 1 6
 SD 2 4
  1. CR complete response, PR partial response, SD stable disease.
  2. aFor MYCN status, 4 of 11 patients with brain metastasis and 27 of 44 patients without brain metastasis had no available data.
  3. bOf 44 patients without brain metastasis, 2 had no data of lactate dehydrogenase. Two and ten patients in group with brain metastasis and without brain metastasis respectively underwent autologous stem cell transplant.