Table 2 Comparison of the clinical characteristics between relapsed patients with and without brain metastasis
From: Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment
Variable | Patients with brain metastasis | Patients without brain metastasis | P value |
|---|---|---|---|
Total (cases) | 11 | 44 | |
Age (years) | |||
Median | 4 | 5 | 0.073 |
Range | 2–10 | 1–10 | |
Sex (cases) | |||
Male | 8 | 30 | 0.632 |
Female | 3 | 14 | |
MYCN status (cases)a | |||
Positive | 2 | 6 | 0.572 |
Negative | 5 | 11 | |
Bone marrow involvement (cases) | |||
Yes | 11 | 35 | 0.101 |
No | 0 | 9 | |
Lactate dehydrogenaseb | |||
Median (U/L) | 568 | 353 | 0.076 |
Range (U/L) | 197–3,906 | 188–3,903 | |
0–500 U/L (cases) | 6 | 23 | 0.533 |
501–1,000 U/L (cases) | 4 | 10 | |
>1,000 U/L (cases) | 1 | 9 | |
Tumor response (cases) | |||
CR | 8 | 34 | 0.719 |
PR | 1 | 6 | |
SD | 2 | 4 | |