Skip to main content

Advertisement

Table 1 Treatment strategies and outcomes of 8 patients with brain metastasis

From: Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment

Patient no. Metastatic site Surgery Radiotherapy Chemotherapy Outcome
1 Bilateral cerebral hemisphere, right temporal lobe No 32.4 Gy IFO + VM26, 4 cycles Died
2 Right frontal lobe Partial resection 25.4 Gy TMZ + CPT-11, 2 cycles; VIP, 5 cycles Died
3 Bilateral frontal lobes No 25.2 Gy No Died
4 Right temporal lobe Complete resection 27.0 Gy whole brain cranial irradiation + 30.0 Gy localized irradiation CPT-11 + TMZ, 6 cycles; CPT-11 + Bevacizumab, 1 cycle Currently alive for 47 months
5 Right frontal lobe, left cerebellum, left frontal lobe, spinal cord Partial resection of the right frontal lobe 30.0 Gy localized irradiation + 30.0 Gy spinal cord irradiation CPT-11 + TMZ, 2 cycles; CPT-11 + Nedaplatin + VCR, 5 cycles Currently alive for 29 months
6 Left cerebellum, medulla No 30.0 Gy localized irradiation CPT-11 + VCR + TMZ, 4 cycles; VIP, 1 cycle Still alive for 30 months
7 Left frontal lobe No No CPT-11 + TMZ, 1 cycle Died
8 Left parietal lobe No No CPT-11 + TMZ, 2 cycles; CPT-11 + Bevacizumab, 1 cycle Died
  1. IFO ifosfamide, VM26 teniposide, TMZ temozolomide, CPT-11 irinotecan, VIP etoposide, ifosfamide, and cisplatinum, VCR vincristine.