Table 1 Treatment strategies and outcomes of 8 patients with brain metastasis
From: Brain metastasis in children with stage 4 neuroblastoma after multidisciplinary treatment
Patient no. | Metastatic site | Surgery | Radiotherapy | Chemotherapy | Outcome |
|---|---|---|---|---|---|
1 | Bilateral cerebral hemisphere, right temporal lobe | No | 32.4 Gy | IFO + VM26, 4 cycles | Died |
2 | Right frontal lobe | Partial resection | 25.4 Gy | TMZ + CPT-11, 2 cycles; VIP, 5 cycles | Died |
3 | Bilateral frontal lobes | No | 25.2 Gy | No | Died |
4 | Right temporal lobe | Complete resection | 27.0 Gy whole brain cranial irradiation + 30.0 Gy localized irradiation | CPT-11 + TMZ, 6 cycles; CPT-11 + Bevacizumab, 1 cycle | Currently alive for 47 months |
5 | Right frontal lobe, left cerebellum, left frontal lobe, spinal cord | Partial resection of the right frontal lobe | 30.0 Gy localized irradiation + 30.0 Gy spinal cord irradiation | CPT-11 + TMZ, 2 cycles; CPT-11 + Nedaplatin + VCR, 5 cycles | Currently alive for 29 months |
6 | Left cerebellum, medulla | No | 30.0 Gy localized irradiation | CPT-11 + VCR + TMZ, 4 cycles; VIP, 1 cycle | Still alive for 30 months |
7 | Left frontal lobe | No | No | CPT-11 + TMZ, 1 cycle | Died |
8 | Left parietal lobe | No | No | CPT-11 + TMZ, 2 cycles; CPT-11 + Bevacizumab, 1 cycle | Died |