Table 3 Cox regression analysis of OS and PFS in 487 patients with NSCLC

Univariate analysis

 Age

≤58 vs. >58

1.058 (0.692–1.618)

0.876 (0.685–1.121)

0.294

 Sex

Male vs. female

0.710 (0.448–1.126)

1.007 (0.781–1.299)

0.958

 Histological type

Adenocarcinoma vs. others

1.971 (1.200–3.235)

1.294 (0.951–1.761)

0.101

 Differentiation

Well vs. poor

0.449 (0.279–0.721)

0.744 (0.576–0.961)

0.023

 Clinical stage

I + II vs. III + IV

3.091 (1.855–5.149)

1.595 (1.202–2.116)

0.001

 Smoking history

Non-smoker vs. smoker

1.779 (1.153–2.747)

1.100 (0.862–1.403)

0.443

 T category

T1–2 vs. T3–4

2.475 (1.605–3.816)

1.582 (1.218–2.055)

0.001

 N category

N0 vs. N1–3

3.155 (1.855–5.366)

1.438 (1.071–1.931)

0.016

 M category

M0 vs. M1

2.275 (1.477–3.503)

1.576 (1.214–2.046)

0.001

 EGFR mutation

Negative vs. positive

0.509 (0.306–0.848)

0.845 (0.647–1.102)

0.213

 ALK rearrangement

Negative vs. positive

1.397 (0.740–2.635)

1.155 (0.785–1.701)

0.465

Multivariate analysis

 Histological type

Adenocarcinoma vs. others

1.926 (1.102–3.364)

–

–

 T category

T1–2 vs. T3–4

–

1.499 (1.144–1.964)

0.003

 N category

N0 vs. N1–3

2.403 (1.166–4.956)

–

–

 M category

M0 vs. M1

2.164 (1.292–3.624)

1.477 (1.105–1.974)

0.008