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Fig. 1 | Chinese Journal of Cancer

Fig. 1

From: Clinicopathologic characteristics and therapeutic responses of Chinese patients with non-small cell lung cancer who harbor an anaplastic lymphoma kinase rearrangement

Fig. 1

Representatives of hematoxylin–eosin (H&E) staining and fluorescence in situ hybridization (FISH) in non–small cell lung cancer (NSCLC) lesions with anaplastic lymphoma kinase (ALK) rearrangement. a An ALK-rearranged adenocarcinoma with a mucinous pattern by H&E staining (×200). b An ALK-rearranged squamous carcinoma with a solid growth pattern by H&E staining (×200). c ALK break-apart signals by FISH with a split orange (staining 3′-2 chromosomal/DNA region) and green (staining 5′-2 chromosomal/DNA region) signal pattern (red arrows), indicating an ALK rearrangement-positive status. d ALK break-apart signals by FISH with an isolated orange signal pattern (yellow arrows), indicating an ALK rearrangement-negative status.

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