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Table 5 Univariate and multivariate analysis in assessing the impact of M subcategories for patients with synchronous metastatic NPC

From: Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

Variable HR 95% CI P
Univariate analysis
 Age (≥48 years/<48 years) 1.32 1.05–1.65 0.016
 Sex (female/male) 0.85 0.62–1.17 0.319
 UICC T category (T3–4/T1–2) 0.93 0.79–1.22 0.930
 UICC N category (N1–3/N0) 1.93 1.12–3.31 0.017
 KPS (< 80/≥ 80) 1.66 1.03–2.67 0.036
 BMI (<18.5/≥18.5) 1.23 0.90–1.67 0.189
 Radiotherapy to primary tumor (yes/no) 0.52 0.41–0.65 <0.001
 Cycles of chemotherapy (>4/≤4) 0.71 0.57–0.89 0.003
 M subcategorya <0.001
  M1a Ref   
  M1b 1.90 1.30–2.76 0.001
  M1c 3.10 2.08–4.62 <0.001
Multivariate analysis
 Age (≥48 years/<4 years) 1.24 0.99–1.56 0.065
 UICC N category (N1–3/N0) 1.83 1.05–3.17 0.032
 Radiotherapy to primary tumor (yes/no) 0.63 0.49–0.80 <0.001
 Cycles of chemotherapy (>4/≤4) 0.63 0.50–0.79 <0.001
 M subcategorya <0.001
  M1a Ref   
  M1b 1.69 1.16–2.48 0.007
  M1c 2.64 1.75–3.98 <0.001
  1. KPS Karnofsky performance score; BMI body mass index; Ref reference; Other abbreviations as in Table 4.
  2. aOne of the 505 patients with an unspecified metastatic disease cannot be classified to any of the three subcategories.