Skip to main content

Table 5 Univariate and multivariate analysis in assessing the impact of M subcategories for patients with synchronous metastatic NPC

From: Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

Variable

HR

95% CI

P

Univariate analysis

 Age (≥48 years/<48 years)

1.32

1.05–1.65

0.016

 Sex (female/male)

0.85

0.62–1.17

0.319

 UICC T category (T3–4/T1–2)

0.93

0.79–1.22

0.930

 UICC N category (N1–3/N0)

1.93

1.12–3.31

0.017

 KPS (< 80/≥ 80)

1.66

1.03–2.67

0.036

 BMI (<18.5/≥18.5)

1.23

0.90–1.67

0.189

 Radiotherapy to primary tumor (yes/no)

0.52

0.41–0.65

<0.001

 Cycles of chemotherapy (>4/≤4)

0.71

0.57–0.89

0.003

 M subcategorya

<0.001

  M1a

Ref

  

  M1b

1.90

1.30–2.76

0.001

  M1c

3.10

2.08–4.62

<0.001

Multivariate analysis

 Age (≥48 years/<4 years)

1.24

0.99–1.56

0.065

 UICC N category (N1–3/N0)

1.83

1.05–3.17

0.032

 Radiotherapy to primary tumor (yes/no)

0.63

0.49–0.80

<0.001

 Cycles of chemotherapy (>4/≤4)

0.63

0.50–0.79

<0.001

 M subcategorya

<0.001

  M1a

Ref

  

  M1b

1.69

1.16–2.48

0.007

  M1c

2.64

1.75–3.98

<0.001

  1. KPS Karnofsky performance score; BMI body mass index; Ref reference; Other abbreviations as in Table 4.
  2. aOne of the 505 patients with an unspecified metastatic disease cannot be classified to any of the three subcategories.