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Table 3 Overall survival (OS) according to the locations, number of locations, and number of lesions in each location

From: Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

Category and variable Number of patientsa Median OS (months) 3-year OS rate (%) P value
Isolated metastasis versus multiple metastases
 Number of metastatic locations     0.001
  Multiple locations 199 22.4 24.0  
  Isolated location 306 27.4 41.6  
 Number of metastatic lesions in each location     <0.001
  Multiple lesions 410 22.8 29.5  
  Isolated lesion 95 41.0 57.6  
Involved locations
 Bone involvement     0.404
  Yes 333 26.2 35.8  
  No 172 23.9 33.5  
 Lung involvement     0.559
  Yes 136 25.1 30.3  
  No 369 24.6 36.6  
 Liver involvement     <0.001
  Yes 155 19.7 21.7  
  No 350 28.4 41.1  
 Distant LN involvement     0.104
  Yes 144 23.2 27.6  
  No 361 26.7 37.6  
Number of lesions and locations
 Isolated bone metastasis     0.065
  Single lesion 50 44.2 60.7  
  Multiple lesions 133 25.0 38.6  
 Isolated lung metastasis     0.115
  Single lesion 20 57.0 62.1  
  Multiple lesions 36 27.2 30.9  
 Isolated liver metastasis     0.473
  Single lesion 21 25.6 43.6  
  Multiple lesions 35 17.8 22.4  
 Isolated distant LN metastasis    
  Single lesion 4 63.7 75.0  
  Multiple lesions 6 21.0 54.5  
 Total isolated metastasisb     0.002
  Single lesion 95 41.0 57.6  
  Multiple lesions 210 23.3 34.6  
  1. LN lymph node.
  2. aThe total number of patients does not coincide exactly with the corresponding number in Table 2 because the number of lesions for some patients is not specified.
  3. bThese include isolated metastasis in the bones, the lungs, the liver, and distant lymph node.