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Table 1 Baseline characteristics of 505 nasopharyngeal carcinoma (NPC) patients with synchronous metastasis

From: Subdivision of M category for nasopharyngeal carcinoma with synchronous metastasis: time to expand the M categorization system

Characteristic Entire group M1 subcategorya P value
M1a M1b M1c
Total 505 74 296 134  
Age (years) 0.426
 <48 259 (51.3) 43 (58.1) 149 (50.3) 66 (49.3)  
 ≥48 246 (48.7) 31 (41.9) 147 (49.7) 68 (50.7)  
Sex 0.212
 Male 427 (84.6) 58 (78.4) 256 (86.5) 112 (83.6)  
 Female 78 (15.4) 16 (21.6) 40 (13.5) 22 (16.4)  
UICC T category 0.756
 T1 25 (5.0) 3 (4.1) 13 (4.4) 8 (6.0)  
 T2 88 (17.4) 14 (18.9) 47 (15.9) 27 (20.1)  
 T3 227 (45.0) 29 (39.2) 139 (47.0) 59 (44.0)  
 T4 165 (32.7) 28 (37.8) 97 (32.8) 40 (29.9)  
UICC N category 0.143
 N0 28 (5.5) 7 (9.5) 18 (6.1) 3 (2.2)  
 N1 160 (31.7) 25 (33.8) 90 (30.4) 44 (32.8)  
 N2 227 (45.0) 35 (47.3) 128 (43.2) 64 (47.8)  
 N3 90 (17.8) 7 (9.5) 60 (20.3) 23 (17.2)  
KPS 0.201b
 ≥80 476 (94.3) 73 (98.6) 276 (93.2) 126 (94.0)  
 <80 29 (5.7) 1 (1.4) 20 (6.8) 8 (6.0)  
BMI      0.699
 ≥18.5 430 (85.1) 65 (87.8) 249 (84.1) 115 (85.8)  
 <18.5 75 (14.9) 9 (12.2) 47 (15.9) 19 (14.2)  
Radiotherapy to primary tumor <0.001
 No 267 (52.9) 22 (29.7) 147 (49.7) 98 (73.1)  
 Yes 238 (47.1) 52 (70.3) 149 (50.3) 36 (26.9)  
Cycles of chemotherapy 0.864
 ≤ 4 273 (54.1) 42 (56.8) 159 (53.7) 71 (53.0)  
 >4 232 (45.9) 32 (43.2) 137 (46.3) 63 (47.0)  
  1. All values are presented as numbers of patients followed by percentages in the parentheses.
  2. UICC International Union Against Cancer, KPS Karnofsky performance score and BMI body mass index.
  3. aOne of the 505 patients with an unspecified metastatic disease cannot be classified to any of the three M1 subcategories.
  4. bFisher’s exact test was used; P < 0.05 was considered significant.