Figure 1

Frequencies of genetic alternations (mutations and copy number changes) in cancer driver genes. The frequencies for the top 30 mutated genes in lung adenocarcinoma, squamous cell carcinoma, and small cell lung cancer were retrieved from http://www.cbioportal.org. TP53 tumor protein p53; KRAS Kirsten rat sarcoma viral oncogene homolog; CDKN2A cyclin-dependent kinase inhibitor 2A; MLL3 mixed-lineage leukemia 3; STK11 serine/threonine kinase 11; KEAP1 kelch-like ECH-associated protein 1; EGFR epidermal growth factor receptor; RIT1 Ras-like without CAAX 1; NKX2-1 NK2 homeobox 1; SETBP1 SET-binding protein 1; ATM ataxia telangiectasia-mutated; CARD11 caspase recruitment domain family, member 11; MET MET proto-oncogene; NF1 neurofibromin1; SKP2 S-phase kinase-associated protein 2; BRAF v-Raf murine sarcoma viral oncogene homolog B1; GNAS GNAS complex locus; MYC v-myc avian myelocytomatosis viral oncogene homolog; MGA MAX dimerization protein; CDC73 cell division cycle 73; PIK3CA phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha; SETD2 SET domain-containing 2; MDM2 mouse double minute 2 homolog; RBM10 RNA-binding motif protein 10; ERBB4 erb-b2 receptor tyrosine kinase 4; ALK anaplastic lymphoma kinase; ARID1A AT rich interactive domain 1A; SOX2 sex-determining region Y-related gene family 2; FGFR1 fibroblast growth factor receptor 1; NFE2L2 nuclear factor, erythroid 2-like 2; CCND1 cyclin D1; PTEN phosphatase and tensin homolog; FOXL2 forkhead box L2; NOTCH2 notch 2; PDGFRA platelet-derived growth factor receptor, alpha polypeptide; KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CREBBP CREB-binding protein; PAX5 paired box 5; SLIT2 slit homolog 2; JAK2 Janus kinase 2; RB1 retinoblastoma 1; SMARCA4 SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4; EP300 E1A-binding protein p300; SMO smoothened; EPHA7 EPH receptor A7; MED12 mediator complex subunit 12; KDM6A lysine (K)-specific demethylase 6A; FAM123B family with sequence similarity 123B; B2M beta-2-microglobulin; CYLD cyclin dromatosis (turban tumor syndrome); GATA2 GATA-binding protein 2; BRCA1 breast cancer early onset.