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Table 5 Pooled ORs and 95 % CIs of TLR3 polymorphisms in the stratified analysis

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

Stratification Number of studies M1 M2 M3 M4 Number of studies M5
OR (95 % CI) P I 2 (%) OR (95 % CI) P I 2 (%) OR (95 % CI) P I 2 (%) OR (95 % CI) P I 2 (%)   OR (95 % CI) P I 2 (%)
rs3775290 (C13766T, C > T)                  
 Ethnicity                  
  Asian 3 1.28 0.036 0 1.79 0.032 0 1.33 0.013 0 1.61 0.08 0 4 1.14 0.25a 58.2
   (1.02-1.62)    (1.05-3.05)    (1.06-1.67)    (0.95-2.71)     (0.91-1.43)   
  Caucasian 2 0.72 0.372 75.5 1.00 0.996 0 0.76 0.45a 75.6 1.35 0.52 0 2 0.89 0.60a 63.6
   (0.34-1.49)    (0.55-1.82)    (0.38-1.54)    (0.54-3.36)     (0.58-1.38)   
 Cancer type                  
  Genital system neoplasms 4 0.97 0.892 75 1.26 0.3 0 1.04 0.73a 73.9 1.33 0.2 0   1.07 0.64a 58.8
   (0.62-1.53)    (0.81-1.95)    (0.84-1.29)    (0.87-2.03)     (0.82-1.39)   
 Source of controls                  
  Hospital-based   NA    NA    NA    NA    5 1.12 0.32a 54.7
                (0.90-1.40)   
  Population-based   NA    NA    NA    NA    1 0.88 0.23  
                (0.70-1.09)   
rs3775291 (G13909A, L412F, G > A)                  
 Cancer type                  
  Digestive tract cancer 3 1.16 0.132a 65.4 1.28 0.429 89.1 1.18 0.186 80.4 1.18 0.559a 87.4 3 1.14 0.288a 87.5
   (0.96-1.41)    (0.69-2.38)    (0.92-1.51)    (0.68-2.05)     (0.90-1.44)   
  Breast cancer 2 1.11 0.118 0 1.04 0.739 0 1.10 0.148 0 0.99 0.911 0 2 1.05 0.288 0
   (0.97-1.27)    (0.70-1.55)    (0.97-1.25)    (0.79-1.23)     (0.96-1.16)   
  Nasopharyngeal carcinoma 1 1.54 0.005   0.81 0.593   1.45 0.012   0.70 0.37   2 1.16 0.083 0
   (1.14-2.09)    (0.37-1.76)    (1.09-1.94)    (0.33-1.52)     (0.98-1.37)   
 Ethnicity                  
  Caucasian 5 1.02 0.613 0 0.98 0.78 4.6 1.02 0.732 0 0.97 0.685 40.9 5 1.00 0.94 0
   (0.94-1.12)    (0.84-1.14)    (0.93-1.11)    (0.84-1.13)     (0.93-1.07)   
  Asian 2 1.27 0.048 a 54 1.76 0.272 91.2 1.33 0.105 80.7 1.55 0.334 89.5 3 1.21 0.108a 79.5
   (1.00-1.60)    (0.64-4.82)    (0.94-1.89)    (0.64-3.77)     (0.96-1.53)   
  African 1 1.23 0.005   0.81 0.593   1.45 0.012   0.70 0.37   1 1.27 0.062  
   (1.06-1.43)    (0.37-1.76)    (1.09-1.94)    (0.33-1.52)     (0.99-1.63)   
 Source of controls                  
  Hospital-based 2 1.50 <0.001 0 1.61 0.466a 86.8 1.54 <0.001 0 1.37 0.616a 86.3 2 1.43 <0.001 32.6
   (1.23-1.83)    (0.45-5.84)    (1.27-1.87)    (0.40-4.76)     (1.23-1.67)   
  Population-based 6 1.05 0.259 0 1.00 0.999 0 1.04 0.338 0 0.98 0.748 26.9 7 1.02 0.465a 0
   (0.97-1.14)    (0.87-1.15)    (0.96-1.12)    (0.86-1.12)     (0.97-1.08)   
 Sample size                  
  Large 5 1.05 0.218 0 0.98 0.823 0 1.04 0.328 0 0.96 0.545 0 5 1.02 0.629 0
   (0.97-1.14)    (0.86-1.13)    (0.96-1.12)    (0.84-1.10)     (0.96-1.08)   
  Small 3 1.41 <0.001 45.6 1.76 0.184a 73.7 1.47 <0.001 21.1 1.63 0.242a 73.9 4 1.30 <0.001 47.9
   (1.16-1.70)    (0.77-4.05)    (1.23-1.76)    (0.72-3.65)     (1.15-1.47)   
rs3775292 (intron 3, C > G)                  
 Cancer type                  
  Colorectal cancer 2 0.93 0.609a 82.2 0.89 0.657a 68 0.93 0.464a 63.8 0.92 0.797a 78.2 2 0.94 0.233 0
   (0.69-1.25)    (0.54-1.48)    (0.76-1.13)    (0.50-1.69)     (0.86-1.04)   
  Breast Cancer 1 1.06 0.601   1.14 0.607   1.07 0.535   1.12 0.656   1 1.06 0.499  
   (0.86-1.30)    (0.69-1.90)    (0.87-1.30)    (0.68-1.86)     (0.90-1.26)   
  Skin malignant melanoma 1 0.91 0.411   1.09 0.753   0.93 0.503   1.12 0.659   1 0.96 0.683  
   (0.73-1.14)    (0.64-1.84)    (0.75-1.15)    (0.67-1.89)     (0.80-1.16)   
rs5743312 (C9948T, intron 3, C > T)                  
 Ethnicity                  
  Asian   NA    NA    NA    NA    2 1.17 0.017 25.3
                (1.03-1.33)   
  Caucasian   NA    NA    NA    NA    2 0.99 0.995 0
                (0.83-1.21)   
 Sample size                  
  Large 2 1.02 0.82 0 1.89 <0.001 4 1.08 0.268 37.2 1.87 0.001 0 2 1.11 0.305a 61.7
   (0.88-1.17)    (1.32-2.70)    (0.94-1.24)    (1.31-2.65)     (0.99-1.24)   
  Small 1 0.99 0.97   1.70 0.569   1.04 0.9   1.70 0.566   2 1.02 0.894 0
   (0.51-1.93)    (0.28-10.45)    (0.55-1.98)    (0.28-10.40)     (0.78-1.32)   
  1. NA, not available. Other footnotes as in Table 4. The bold means the significant results.