Table 5 Pooled ORs and 95 % CIs of TLR3 polymorphisms in the stratified analysis
From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis
Stratification | Number of studies | M1 | M2 | M3 | M4 | Number of studies | M5 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95 % CI) | P | I 2 (%) | OR (95 % CI) | P | I 2 (%) | OR (95 % CI) | P | I 2 (%) | OR (95 % CI) | P | I 2 (%) | OR (95 % CI) | P | I 2 (%) | |||
rs3775290 (C13766T, C > T) | |||||||||||||||||
Ethnicity | |||||||||||||||||
Asian | 3 | 1.28 | 0.036 | 0 | 1.79 | 0.032 | 0 | 1.33 | 0.013 | 0 | 1.61 | 0.08 | 0 | 4 | 1.14 | 0.25a | 58.2 |
(1.02-1.62) | (1.05-3.05) | (1.06-1.67) | (0.95-2.71) | (0.91-1.43) | |||||||||||||
Caucasian | 2 | 0.72 | 0.372 | 75.5 | 1.00 | 0.996 | 0 | 0.76 | 0.45a | 75.6 | 1.35 | 0.52 | 0 | 2 | 0.89 | 0.60a | 63.6 |
(0.34-1.49) | (0.55-1.82) | (0.38-1.54) | (0.54-3.36) | (0.58-1.38) | |||||||||||||
Cancer type | |||||||||||||||||
Genital system neoplasms | 4 | 0.97 | 0.892 | 75 | 1.26 | 0.3 | 0 | 1.04 | 0.73a | 73.9 | 1.33 | 0.2 | 0 | 1.07 | 0.64a | 58.8 | |
(0.62-1.53) | (0.81-1.95) | (0.84-1.29) | (0.87-2.03) | (0.82-1.39) | |||||||||||||
Source of controls | |||||||||||||||||
Hospital-based | NA | NA | NA | NA | 5 | 1.12 | 0.32a | 54.7 | |||||||||
(0.90-1.40) | |||||||||||||||||
Population-based | NA | NA | NA | NA | 1 | 0.88 | 0.23 | ||||||||||
(0.70-1.09) | |||||||||||||||||
rs3775291 (G13909A, L412F, G > A) | |||||||||||||||||
Cancer type | |||||||||||||||||
Digestive tract cancer | 3 | 1.16 | 0.132a | 65.4 | 1.28 | 0.429 | 89.1 | 1.18 | 0.186 | 80.4 | 1.18 | 0.559a | 87.4 | 3 | 1.14 | 0.288a | 87.5 |
(0.96-1.41) | (0.69-2.38) | (0.92-1.51) | (0.68-2.05) | (0.90-1.44) | |||||||||||||
Breast cancer | 2 | 1.11 | 0.118 | 0 | 1.04 | 0.739 | 0 | 1.10 | 0.148 | 0 | 0.99 | 0.911 | 0 | 2 | 1.05 | 0.288 | 0 |
(0.97-1.27) | (0.70-1.55) | (0.97-1.25) | (0.79-1.23) | (0.96-1.16) | |||||||||||||
Nasopharyngeal carcinoma | 1 | 1.54 | 0.005 | 0.81 | 0.593 | 1.45 | 0.012 | 0.70 | 0.37 | 2 | 1.16 | 0.083 | 0 | ||||
(1.14-2.09) | (0.37-1.76) | (1.09-1.94) | (0.33-1.52) | (0.98-1.37) | |||||||||||||
Ethnicity | |||||||||||||||||
Caucasian | 5 | 1.02 | 0.613 | 0 | 0.98 | 0.78 | 4.6 | 1.02 | 0.732 | 0 | 0.97 | 0.685 | 40.9 | 5 | 1.00 | 0.94 | 0 |
(0.94-1.12) | (0.84-1.14) | (0.93-1.11) | (0.84-1.13) | (0.93-1.07) | |||||||||||||
Asian | 2 | 1.27 | 0.048 a | 54 | 1.76 | 0.272 | 91.2 | 1.33 | 0.105 | 80.7 | 1.55 | 0.334 | 89.5 | 3 | 1.21 | 0.108a | 79.5 |
(1.00-1.60) | (0.64-4.82) | (0.94-1.89) | (0.64-3.77) | (0.96-1.53) | |||||||||||||
African | 1 | 1.23 | 0.005 | 0.81 | 0.593 | 1.45 | 0.012 | 0.70 | 0.37 | 1 | 1.27 | 0.062 | |||||
(1.06-1.43) | (0.37-1.76) | (1.09-1.94) | (0.33-1.52) | (0.99-1.63) | |||||||||||||
Source of controls | |||||||||||||||||
Hospital-based | 2 | 1.50 | <0.001 | 0 | 1.61 | 0.466a | 86.8 | 1.54 | <0.001 | 0 | 1.37 | 0.616a | 86.3 | 2 | 1.43 | <0.001 | 32.6 |
(1.23-1.83) | (0.45-5.84) | (1.27-1.87) | (0.40-4.76) | (1.23-1.67) | |||||||||||||
Population-based | 6 | 1.05 | 0.259 | 0 | 1.00 | 0.999 | 0 | 1.04 | 0.338 | 0 | 0.98 | 0.748 | 26.9 | 7 | 1.02 | 0.465a | 0 |
(0.97-1.14) | (0.87-1.15) | (0.96-1.12) | (0.86-1.12) | (0.97-1.08) | |||||||||||||
Sample size | |||||||||||||||||
Large | 5 | 1.05 | 0.218 | 0 | 0.98 | 0.823 | 0 | 1.04 | 0.328 | 0 | 0.96 | 0.545 | 0 | 5 | 1.02 | 0.629 | 0 |
(0.97-1.14) | (0.86-1.13) | (0.96-1.12) | (0.84-1.10) | (0.96-1.08) | |||||||||||||
Small | 3 | 1.41 | <0.001 | 45.6 | 1.76 | 0.184a | 73.7 | 1.47 | <0.001 | 21.1 | 1.63 | 0.242a | 73.9 | 4 | 1.30 | <0.001 | 47.9 |
(1.16-1.70) | (0.77-4.05) | (1.23-1.76) | (0.72-3.65) | (1.15-1.47) | |||||||||||||
rs3775292 (intron 3, C > G) | |||||||||||||||||
Cancer type | |||||||||||||||||
Colorectal cancer | 2 | 0.93 | 0.609a | 82.2 | 0.89 | 0.657a | 68 | 0.93 | 0.464a | 63.8 | 0.92 | 0.797a | 78.2 | 2 | 0.94 | 0.233 | 0 |
(0.69-1.25) | (0.54-1.48) | (0.76-1.13) | (0.50-1.69) | (0.86-1.04) | |||||||||||||
Breast Cancer | 1 | 1.06 | 0.601 | 1.14 | 0.607 | 1.07 | 0.535 | 1.12 | 0.656 | 1 | 1.06 | 0.499 | |||||
(0.86-1.30) | (0.69-1.90) | (0.87-1.30) | (0.68-1.86) | (0.90-1.26) | |||||||||||||
Skin malignant melanoma | 1 | 0.91 | 0.411 | 1.09 | 0.753 | 0.93 | 0.503 | 1.12 | 0.659 | 1 | 0.96 | 0.683 | |||||
(0.73-1.14) | (0.64-1.84) | (0.75-1.15) | (0.67-1.89) | (0.80-1.16) | |||||||||||||
rs5743312 (C9948T, intron 3, C > T) | |||||||||||||||||
Ethnicity | |||||||||||||||||
Asian | NA | NA | NA | NA | 2 | 1.17 | 0.017 | 25.3 | |||||||||
(1.03-1.33) | |||||||||||||||||
Caucasian | NA | NA | NA | NA | 2 | 0.99 | 0.995 | 0 | |||||||||
(0.83-1.21) | |||||||||||||||||
Sample size | |||||||||||||||||
Large | 2 | 1.02 | 0.82 | 0 | 1.89 | <0.001 | 4 | 1.08 | 0.268 | 37.2 | 1.87 | 0.001 | 0 | 2 | 1.11 | 0.305a | 61.7 |
(0.88-1.17) | (1.32-2.70) | (0.94-1.24) | (1.31-2.65) | (0.99-1.24) | |||||||||||||
Small | 1 | 0.99 | 0.97 | 1.70 | 0.569 | 1.04 | 0.9 | 1.70 | 0.566 | 2 | 1.02 | 0.894 | 0 | ||||
(0.51-1.93) | (0.28-10.45) | (0.55-1.98) | (0.28-10.40) | (0.78-1.32) | |||||||||||||