Skip to main content

Advertisement

Table 4 Pooled ORs and 95 % CIs of TLR3 polymorphisms in this meta-analysis

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

SNP Number of studies M1 M2 M3 M4 Number of studies M5
OR (95 % CI) P I 2 (%) OR (95 % CI) P I2 (%) OR (95 % CI) P I2 (%) OR (95 % CI) P I2 (%) OR (95 % CI) P I2 (%)
rs3775290 (C13766T, C > T) 5 1.04 0.854* 70.0 1.38 0.110 0.0 1.09 0.640* 69.4 1.41 0.082 0.0 6 1.06 0.550 59.3
  (0.72-1.49)    (0.93-2.06)    (0.77-1.53)    (0.96-2.08)     (0.87-1.30)   
rs3775291 (G13909A, L412F, G > A) 8 1.12 0.056* 53.9 1.13 0.335* 66.5 1.12 0.054* 58.6 1.08 0.507* 65.2 9 1.09 0.064* 59.5
(1.00-1.26)    (0.88-1.45)    (1.00-1.26)    (0.86-1.37)     (1.00-1.19)   
rs3775292 (C/G, intron 3, C > G) 4 0.96 0.554* 54.5 0.93 0.500 34.7 0.97 0.476 23.1 0.94 0.554 49.9 4 0.97 0.416 0.0
(0.83-1.11)    (0.75-1.15)    (0.89-1.06)    (0.76-1.16)     (0.90-1.05)   
rs5743312 (C9948T, intron 3, C > T) 3 1.02 0.832 0.0 1.88 <0.001 0.0 1.08 0.267 0.0 1.86 <0.001 0.0 4 1.11 0.047 7.1
(0.88-1.17)    (1.33-2.67)    (0.94-1.23)    (1.32-2.63)     (1.00-1.24)   
  1. OR, odds ratio; CI, confidence interval. *The heterogeneity exists; a random-effect model based on the DerSimonian and Laird method or a fixed-effect model based on the Mantel-Haenszel method was used. M1: Aa vs. AA, heterozygote comparison; M2: aa vs. AA, homozygote comparison; M3: Aa + aa vs. AA, dominant model; M4: aa vs. AA + Aa, recessive model; M5: a vs. A, allelic model (A indicates wild allele, a indicates variant allele). The bold means the significant results.