TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

Wang, Ben-Gang; Yi, De-Hui; Liu, Yong-Feng

doi:10.1186/s40880-015-0020-z

Cancer Communications

Table 3 Characteristics of the 14 studies included for this meta-analysis

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

Study	Ethnicity	Cancer type	Sample size		Cases			Controls			P of HWE
Study	Ethnicity	Cancer type	Case	Control	wt/wt	wt/var	var/var	wt/wt	wt/var	var/var	P of HWE
rs3775290 (C13766T, C > T)
He et al. [4]	Asian	Nasopharyngeal carcinoma	395	371	565^*		225^*	510^*		232^a
Singh et al. [5]	Asian	Bladder cancer	200	200	106	81	13	122	71	7	0.391
Mandal et al. [6]	Asian	Prostate cancer	195	250	115	68	12	157	84	9	0.585
Pandey et al. [7]	Asian	Cervical cancer	200	200	91	98	11	110	81	9	0.217
Etokebe et al. [8]	Caucasian	Breast cancer	130	101	58	56	14	46	42	8	0.713
Zidi et al. [22]	Caucasian	Cervical cancer	130	200	69	48	13	76	106	18	0.026
rs3775291 (G13909A, L412F, G > A)
He et al. [4]	Asian	Nasopharyngeal carcinoma	333	287	405^*		261^*	359^a		215^a
Li et al. [9]	Asian	Hepatocellular carcinoma	466	482	192	222	52	256	203	23	0.030
Lei et al. [15]	Asian	Breast cancer	981	1221	447	431	103	594	500	127	0.155
Gast et al. [16]	Caucasian	Skin malignant melanoma	732	668	379	291	62	332	284	52	0.415
Slattery et al. [17]	Caucasian	Colon cancer	1554	1955	748	653	153	947	817	191	0.446
		Rectal cancer	754	959	363	332	59	478	381	100	0.066
Resler et al. [18]	Caucasian	Breast cancer	840	801	427	348	65	418	318	65	0.679
Zeljic et al. [19]	Caucasian	Oral squamous cell carcinomas	93	104	39	39	15	43	53	8	0.128
Moumad et al. [21]	African	Nasopharyngeal carcinoma	472	362	289	170	13	252	96	14	0.210
rs3775292 (C/G, intron 3, C > G)
Gast et al. [16]	Caucasian	Skin malignant melanoma	730	668	464	233	33	413	228	27	0.521
Slattery et al. [17]	Caucasian	Colon cancer	1554	1956	990	507	57	1253	601	102	0.008
		Rectal cancer	754	959	494	222	38	586	335	38	0.247
Resler et al. [18]	Caucasian	Breast cancer	840	800	522	284	34	509	262	29	0.507
rs5743312 (C9948T, intron 3, C > T)
He et al. [4]	Asian	Nasopharyngeal carcinoma	405	200	640^*		170^a	316^*		84^a
Lei et al. [15]	Asian	Breast cancer	996	1245	582	348	66	770	433	42	0.044
Gast et al. [16]	Caucasian	Skin malignant melanoma	716	657	500	200	16	453	193	11	0.060
Zeljic et al. [19]	Caucasian	Oral squamous cell carcinomas	93	104	69	21	3	78	24	2	0.923

wt/wt, wild type/wild type, indicating wild genotype; wt/var, wild type/variant type, indicating heterozygote; var/var, variant type/variant type, indicating variant genotype; HWE, Hardy-Weinberg equilibrium. ^*Only the data of allelic model were available, and thus the studies were analyzed only when the allelic model was used. The bold means the genotype information of the rs3775291 and rs3775292 SNPs that readers could not found in [17], and these data were kindly provided by the contacted authors.

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ISSN: 2523-3548

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