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Table 3 Characteristics of the 14 studies included for this meta-analysis

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

Study Ethnicity Cancer type Sample size Cases Controls P of HWE
Case Control wt/wt wt/var var/var wt/wt wt/var var/var
rs3775290 (C13766T, C > T)          
 He et al. [4] Asian Nasopharyngeal carcinoma 395 371 565*   225* 510*   232a  
 Singh et al. [5] Asian Bladder cancer 200 200 106 81 13 122 71 7 0.391
 Mandal et al. [6] Asian Prostate cancer 195 250 115 68 12 157 84 9 0.585
 Pandey et al. [7] Asian Cervical cancer 200 200 91 98 11 110 81 9 0.217
 Etokebe et al. [8] Caucasian Breast cancer 130 101 58 56 14 46 42 8 0.713
 Zidi et al. [22] Caucasian Cervical cancer 130 200 69 48 13 76 106 18 0.026
rs3775291 (G13909A, L412F, G > A)          
 He et al. [4] Asian Nasopharyngeal carcinoma 333 287 405*   261* 359a   215a  
 Li et al. [9] Asian Hepatocellular carcinoma 466 482 192 222 52 256 203 23 0.030
 Lei et al. [15] Asian Breast cancer 981 1221 447 431 103 594 500 127 0.155
 Gast et al. [16] Caucasian Skin malignant melanoma 732 668 379 291 62 332 284 52 0.415
 Slattery et al. [17] Caucasian Colon cancer 1554 1955 748 653 153 947 817 191 0.446
   Rectal cancer 754 959 363 332 59 478 381 100 0.066
 Resler et al. [18] Caucasian Breast cancer 840 801 427 348 65 418 318 65 0.679
 Zeljic et al. [19] Caucasian Oral squamous cell carcinomas 93 104 39 39 15 43 53 8 0.128
 Moumad et al. [21] African Nasopharyngeal carcinoma 472 362 289 170 13 252 96 14 0.210
rs3775292 (C/G, intron 3, C > G)          
 Gast et al. [16] Caucasian Skin malignant melanoma 730 668 464 233 33 413 228 27 0.521
 Slattery et al. [17] Caucasian Colon cancer 1554 1956 990 507 57 1253 601 102 0.008
   Rectal cancer 754 959 494 222 38 586 335 38 0.247
 Resler et al. [18] Caucasian Breast cancer 840 800 522 284 34 509 262 29 0.507
rs5743312 (C9948T, intron 3, C > T)          
 He et al. [4] Asian Nasopharyngeal carcinoma 405 200 640*   170a 316*   84a  
 Lei et al. [15] Asian Breast cancer 996 1245 582 348 66 770 433 42 0.044
 Gast et al. [16] Caucasian Skin malignant melanoma 716 657 500 200 16 453 193 11 0.060
 Zeljic et al. [19] Caucasian Oral squamous cell carcinomas 93 104 69 21 3 78 24 2 0.923
  1. wt/wt, wild type/wild type, indicating wild genotype; wt/var, wild type/variant type, indicating heterozygote; var/var, variant type/variant type, indicating variant genotype; HWE, Hardy-Weinberg equilibrium. *Only the data of allelic model were available, and thus the studies were analyzed only when the allelic model was used. The bold means the genotype information of the rs3775291 and rs3775292 SNPs that readers could not found in [17], and these data were kindly provided by the contacted authors.