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Table 2 The associations between TLR3 polymorphisms and cancer risk in the 14 selected studies

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

TLR3 SNP Location Association(s) with tumor(s)
rs10025405 3′-near gene Breast cancer, associated [20]
rs11721827 Intron 1 Nasopharyngeal carcinoma, associated [4]
   Colorectal cancer, associated [17]
rs11730143 Intron 1 Melanoma, not associated [16]
rs13126816 Intron 1 Melanoma, not associated [16]
rs3775290 Exon 4 Nasopharyngeal carcinoma, not associated [4]
   Bladder cancer, not associated [5]
   Prostate cancer, not associated [6]
   Cervical cancer, not associated [7]
   Breast cancer, not associated [8]
   Cervical cancer, associated [22]
rs3775291 Exon 4, L412F Nasopharyngeal carcinoma, not associated [4]
   Hepatocellular carcinoma, associated [9]
   Breast cancer, not associated [15]
   Melanoma, not associated [16]
   Colorectal cancer, not associated [17]
   Breast cancer, not associated [18]
   Oral cancer, associated [19]
   Nasopharyngeal carcinoma, associated [21]
rs3775292 Intron 3 Melanoma, not associated [16]
   Colorectal cancer, associated [17]
   Breast cancer, not associated [18]
rs5743305 5′-near gene Hepatocellular carcinoma, not associated [9]
   Colorectal cancer, not associated [17]
rs5743312 Intron 3 Nasopharyngeal carcinoma, not associated [4]
   Melanoma, not associated [16]
   Oral cancer, associated with survival [19]
rs7657186 Intron 1 Melanoma, not associated [16]
   Breast cancer, not associated [20]
rs7668666 Intron 3 Melanoma, not associated [16]