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Table 2 The associations between TLR3 polymorphisms and cancer risk in the 14 selected studies

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

TLR3 SNP

Location

Association(s) with tumor(s)

rs10025405

3′-near gene

Breast cancer, associated [20]

rs11721827

Intron 1

Nasopharyngeal carcinoma, associated [4]

  

Colorectal cancer, associated [17]

rs11730143

Intron 1

Melanoma, not associated [16]

rs13126816

Intron 1

Melanoma, not associated [16]

rs3775290

Exon 4

Nasopharyngeal carcinoma, not associated [4]

  

Bladder cancer, not associated [5]

  

Prostate cancer, not associated [6]

  

Cervical cancer, not associated [7]

  

Breast cancer, not associated [8]

  

Cervical cancer, associated [22]

rs3775291

Exon 4, L412F

Nasopharyngeal carcinoma, not associated [4]

  

Hepatocellular carcinoma, associated [9]

  

Breast cancer, not associated [15]

  

Melanoma, not associated [16]

  

Colorectal cancer, not associated [17]

  

Breast cancer, not associated [18]

  

Oral cancer, associated [19]

  

Nasopharyngeal carcinoma, associated [21]

rs3775292

Intron 3

Melanoma, not associated [16]

  

Colorectal cancer, associated [17]

  

Breast cancer, not associated [18]

rs5743305

5′-near gene

Hepatocellular carcinoma, not associated [9]

  

Colorectal cancer, not associated [17]

rs5743312

Intron 3

Nasopharyngeal carcinoma, not associated [4]

  

Melanoma, not associated [16]

  

Oral cancer, associated with survival [19]

rs7657186

Intron 1

Melanoma, not associated [16]

  

Breast cancer, not associated [20]

rs7668666

Intron 3

Melanoma, not associated [16]