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Table 1 The studies included in this systematic review for the association between Toll-like receptor 3 (TLR3) single nucleotide polymorphisms (SNPs) and the risk of developing cancer

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

Publication year

Study

Country

Sample size

Source of controls

Genotyping method

Matched factors

Adjusted factors

 

Cases

Controls

2007

He et al. [4]

China

434

512

Population-based

Sequencing

Sex and age matched

None

2009

Etokebe et al. [8]

Croatia

130

101

Population-based

qPCR

All females, age not matched

None

2010

Lei et al. [15]

China

981

1221

Population-based

SNP Stream

All females, age matched

Age and BMI

2011

Pandey et al. [7]

India

200

200

Not mentioned, only healthy controls

PCR-RFLP

All females, age matched

Age

Gast et al. [16]

Germany

763

736

Hospital-based

Two multiplex PCR

Sex not mentioned, age not matched

None

2012

Mandal et al. [6]

India

195

250

Hospital-based

PCR-RFLP

All males, age matched

 

Slattery et al.[17]

USA

2309

2915

Population-based

Multiplexed bead array

Sex and age matched

None

2013

Singh et al. [5]

India

200

200

Hospital-based

PCR-RFLP

Sex and age matched

Age, sex, and smoking

Li et al. [9]

China

466

482

Population-based

PCR-RFLP

Sex and age matched

Sex and age

Resler et al. [18]

USA

840

800

Population-based

Chip

All females, age matched

Age

Zeljic et al. [19]

Yugoslavia

93

104

Not mentioned, only healthy controls

qPCR

Sex and age matched

Sex, age, smoking, and alcohol consumption

Yeyeodu et al. [20]

USA

102

72

Hospital-based

SNP Stream

All females, age not mentioned

None

Moumad et al. [21]

Germany

472

362

Hospital-based

KASPar

Sex and age matched

Sex and age

2014

Zidi et al. [22]

Tunisia

130

200

Hospital-based

PCR-RFLP

All females, age not matched

None

  1. qPCR, quantitative polymerase chain reaction; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; KASPar, KASPar SNP genotyping system; BMI, body mass index.