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Table 1 The studies included in this systematic review for the association between Toll-like receptor 3 (TLR3) single nucleotide polymorphisms (SNPs) and the risk of developing cancer

From: TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis

Publication year Study Country Sample size Source of controls Genotyping method Matched factors Adjusted factors
  Cases Controls
2007 He et al. [4] China 434 512 Population-based Sequencing Sex and age matched None
2009 Etokebe et al. [8] Croatia 130 101 Population-based qPCR All females, age not matched None
2010 Lei et al. [15] China 981 1221 Population-based SNP Stream All females, age matched Age and BMI
2011 Pandey et al. [7] India 200 200 Not mentioned, only healthy controls PCR-RFLP All females, age matched Age
Gast et al. [16] Germany 763 736 Hospital-based Two multiplex PCR Sex not mentioned, age not matched None
2012 Mandal et al. [6] India 195 250 Hospital-based PCR-RFLP All males, age matched  
Slattery et al.[17] USA 2309 2915 Population-based Multiplexed bead array Sex and age matched None
2013 Singh et al. [5] India 200 200 Hospital-based PCR-RFLP Sex and age matched Age, sex, and smoking
Li et al. [9] China 466 482 Population-based PCR-RFLP Sex and age matched Sex and age
Resler et al. [18] USA 840 800 Population-based Chip All females, age matched Age
Zeljic et al. [19] Yugoslavia 93 104 Not mentioned, only healthy controls qPCR Sex and age matched Sex, age, smoking, and alcohol consumption
Yeyeodu et al. [20] USA 102 72 Hospital-based SNP Stream All females, age not mentioned None
Moumad et al. [21] Germany 472 362 Hospital-based KASPar Sex and age matched Sex and age
2014 Zidi et al. [22] Tunisia 130 200 Hospital-based PCR-RFLP All females, age not matched None
  1. qPCR, quantitative polymerase chain reaction; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; KASPar, KASPar SNP genotyping system; BMI, body mass index.