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Table 6 Dosimetric comparisons of plans with pre-correction margins and plans with post-correction margins for OARs in 40 NPC patients

From: Dosimetric benefit to organs at risk following margin reductions in nasopharyngeal carcinoma treated with intensity-modulated radiation therapy

Organ

Dose index

Plans with pre-correction margins

Plans with post-correction margins

Difference

P value

BrainStem_PRV

D1% (Gy)

56.93ā€‰Ā±ā€‰5.48

55.62ā€‰Ā±ā€‰5.23

1.31ā€‰Ā±ā€‰1.08

<0.001

SpinalCord_PRV

D1% (Gy)

37.95ā€‰Ā±ā€‰3.81

36.91ā€‰Ā±ā€‰3.45

1.04ā€‰Ā±ā€‰1.41

<0.001

OpticNerve_L_PRV

D1% (Gy)

51.89ā€‰Ā±ā€‰15.01

50.97ā€‰Ā±ā€‰14.48

0.91ā€‰Ā±ā€‰2.20

0.012

OpticNerve_R_PRV

D1% (Gy)

51.58ā€‰Ā±ā€‰16.49

50.90ā€‰Ā±ā€‰16.57

0.68ā€‰Ā±ā€‰2.81

0.134

Chiasm_PRV

D1% (Gy)

58.84ā€‰Ā±ā€‰13.35

58.63ā€‰Ā±ā€‰12.90

0.21ā€‰Ā±ā€‰2.36

0.578

Lens_L

Dmax (Gy)

5.85ā€‰Ā±ā€‰1.81

5.81ā€‰Ā±ā€‰1.82

0.04ā€‰Ā±ā€‰0.23

0.327

Lens_R

Dmax (Gy)

5.88ā€‰Ā±ā€‰1.86

5.84ā€‰Ā±ā€‰1.84

0.04ā€‰Ā±ā€‰0.21

0.223

Parotid_L

Dmean (Gy)

37.31ā€‰Ā±ā€‰4.29

34.66ā€‰Ā±ā€‰4.17

2.65ā€‰Ā±ā€‰1.33

<0.001

Ā 

V30Gy (%)

60.81ā€‰Ā±ā€‰15.83

53.35ā€‰Ā±ā€‰15.39

7.46ā€‰Ā±ā€‰7.18

<0.001

Parotid_R

Dmean (Gy)

37.31ā€‰Ā±ā€‰4.08

34.44ā€‰Ā±ā€‰4.20

2.87ā€‰Ā±ā€‰1.42

<0.001

Ā 

V30Gy (%)

61.16ā€‰Ā±ā€‰15.25

52.27ā€‰Ā±ā€‰15.92

8.89ā€‰Ā±ā€‰8.51

<0.001

TemporalLobe_L

D1% (Gy)

63.67ā€‰Ā±ā€‰6.94

62.73ā€‰Ā±ā€‰7.47

0.94ā€‰Ā±ā€‰2.17

0.009

TemporalLobe_R

D1% (Gy)

64.58ā€‰Ā±ā€‰6.24

63.14ā€‰Ā±ā€‰6.35

1.44ā€‰Ā±ā€‰2.03

<0.001

Mandible_L

D1cc (Gy)

60.24ā€‰Ā±ā€‰3.43

58.56ā€‰Ā±ā€‰4.36

1.67ā€‰Ā±ā€‰2.10

<0.001

Mandible_R

D1cc (Gy)

60.28ā€‰Ā±ā€‰4.56

58.28ā€‰Ā±ā€‰5.18

2.00ā€‰Ā±ā€‰1.83

<0.001

TMjoint_L

D1cc (Gy)

44.67ā€‰Ā±ā€‰10.59

42.16ā€‰Ā±ā€‰10.79

2.51ā€‰Ā±ā€‰4.24

0.001

TMjoint_R

D1cc (Gy)

45.46ā€‰Ā±ā€‰12.14

43.40ā€‰Ā±ā€‰10.99

2.06ā€‰Ā±ā€‰3.25

<0.001

Ear_Inner_L

Dmean (Gy)

49.36ā€‰Ā±ā€‰7.98

47.69ā€‰Ā±ā€‰7.67

1.67ā€‰Ā±ā€‰1.61

<0.001

Ear_Inner_R

Dmean (Gy)

49.86ā€‰Ā±ā€‰8.42

48.00ā€‰Ā±ā€‰8.17

1.87ā€‰Ā±ā€‰2.22

<0.001

Larynx

Dmean (Gy)

47.09ā€‰Ā±ā€‰2.57

45.98ā€‰Ā±ā€‰2.52

1.11ā€‰Ā±ā€‰1.46

<0.001

  1. All data are presented as meanā€‰Ā±ā€‰SD of 40 patients. V30Gy, percentage volume receiving at least 30Ā Gy. Other abbreviations as in TablesĀ 3 and 4.