|
Factor
|
Without HBV reactivation [cases (%)]
|
With HBV reactivation [cases (%)]
|
P
value
|
|---|
|
Total
|
159
|
6
| |
|
HBcAb
| | |
0.001
|
|
–
|
110 (69.2)
|
0 (0)
| |
|
+
|
49 (30.8)
|
6 (100.0)
| |
|
Age (years)
| | |
0.237
|
|
≤60
|
65 (40.9)
|
4 (66.7)
| |
|
>60
|
94 (59.1)
|
2 (33.3)
| |
|
Sex
| | |
1.000
|
|
Female
|
66 (41.5)
|
2 (33.3)
| |
|
Male
|
93 (58.5)
|
4 (66.7)
| |
|
ECOG PS
| | |
1.000
|
|
0–1
|
137 (86.2)
|
5 (83.3)
| |
|
≥2
|
22 (13.8)
|
1 (16.7)
| |
|
Bulky mass
| | |
0.343
|
|
Yes
|
115 (72.3)
|
6 (100.0)
| |
|
No
|
44 (27.7)
|
0 (0)
| |
|
B symptoms
| | |
1.000
|
|
–
|
118 (74.2)
|
5 (83.3)
| |
|
+
|
41 (25.8)
|
1 (16.7)
| |
|
Ann Arbor stage†
| | |
0.211
|
|
I–II
|
79 (49.7)
|
1 (16.7)
| |
|
III-IV
|
79 (49.7)
|
5 (83.3)
| |
|
Liver involvement
| | |
1.000
|
|
–
|
151 (95.0)
|
6 (100.0)
| |
|
+
|
8 (5.0)
|
0 (0)
| |
|
Spleen involvement
| | |
0.441
|
|
–
|
145 (91.2)
|
5 (83.3)
| |
|
+
|
14 (8.8)
|
1 (16.7)
| |
|
Involved extranodal sites
| | |
0.627
|
|
<2
|
122 (76.7)
|
4 (66.7)
| |
|
≥2
|
37 (23.3)
|
2 (33.3)
| |
|
Bone marrow involvement
| | |
1.000
|
|
–
|
148 (93.1)
|
6 (100.0)
| |
|
+
|
11 (6.9)
|
0 (0)
| |
|
IPI score†
| | |
0.402
|
|
0–1
|
68 (42.8)
|
1 (16.7)
| |
|
2–5
|
90 (56.6)
|
5 (83.3)
| |
|
HBeAb
| | |
0.094
|
|
–
|
146 (91.8)
|
4 (66.7)
| |
|
+
|
13 (8.2)
|
2 (33.3)
| |
|
ALT
| | |
0.597
|
|
≤40 U/L
|
136 (85.5)
|
6 (100.0)
| |
|
>40 U/L
|
23 (14.5)
|
0 (0)
| |
|
AST
| | |
0.526
|
|
≤45 U/L
|
141 (88.7)
|
5 (83.3)
| |
|
>45 U/L
|
18 (11.3)
|
1 (16.7)
| |
|
TB
| | |
0.463
|
|
≤20.5 μmol/L
|
144 (90.6)
|
5 (83.3)
| |
|
>20.5 μmol/L
|
15 (9.4)
|
1 (16.7)
| |
|
LDH
| | |
0.681
|
|
≤245 U/mL
|
97 (61.0)
|
3 (50.0)
| |
|
>245 U/mL
|
62 (39.0)
|
3 (50.0)
| |
- HBV, hepatitis B virus. Other footnotes as in Table 1.
