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Table 3 Comparison of clinical and pathologic characteristics between HCAs and HCAs with malignant transformation

From: Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers

Variable HCA group ( n= 17) HCC group ( n= 5) Statistic P value
Age (years)    t = 0.935 0.361
 Mean 33 46   
 Range 27–71 40–53   
Sex (cases)     0.040
 Male 7 5   
 Female 10 0   
Alcohol intake (cases)     0.548
 Yes 3 2   
 No 14 3   
Overweight (cases)     0.274
 Yes (BMI ≥ 25 kg/m2) 4 3   
 No (BMI < 25 kg/m2) 13 2   
HBsAg (cases)     1.000
 Positive 1 0   
 Negative 16 5   
AFP (ng/mL) 1.90 (1.51, 2.99) 4.37 (2.63, 6.52) U = 9 0.009
ALT (U/L) 22 (13, 27) 31 (18, 40) U = 26 0.195
GGT (U/L) 23 (13, 44) 62 (29, 122) U = 18 0.055
TBIL (μmol/L) 8.7 (5.8, 9.8) 12.4 (8.3, 18.1) U = 22 0.108
ALB (g/L) 41.3 ± 4.1 42.4 ± 2.6 t = 0.571 0.574
PLT (×109/L)   187.2 ± 40.99   227.6 ± 49.04 t = 1.857 0.078
INR 1.00 (0.93, 1.03) 0.94 (0.91, 0.98) U = 27.5 0.238
Number of tumors (cases)     1.000
 1 14 5   
 ≥2 3 0   
Tumor diameter (cm) 6.5 (3.5, 9.0) 10.0 (2.3, 13.0) U = 37 0.666
  1. HCA group includes HCAs without malignant transformation; HCC group includes HCAs with malignant transformation. Continuous variables of normal distribution were expressed as mean ± standard deviation and compared by using the independent t test. Continuous variables of non-normal distribution were expressed as medians with IQRs in parentheses and compared by using the Mann–Whitney U test. Categorical variables were compared by using the Fisher’s exact test.
  2. GGT, gamma-glutamyl transferase; PLT, platelets; INR, international normalized ratio. Other abbreviations as in Table 2.