Figure 1From: The role of interleukin-18 in glioblastoma pathology implies therapeutic potential of two old drugs—disulfiram and ritonavir Feed-forward interleukin-18 (IL-18) cycle. Schematic summary of the growth-enhancing feed-forward cycle reported by Yeh et al. [5] shows that microglial-synthesized IL-18 (red triangles) facilitates the migration of glioblastoma and that glioblastoma-synthesized fibronectin (F) or vitronectin (V) stimulates microglial IL-18 synthesis.Back to article page