Metabolic syndrome is associated with better prognosis in patients with tongue squamous cell carcinoma

Cancer Communications

Table 2 Univariate and multivariate Cox regression analyses for overall survival in patients with TSCC

Variable	Univariate analysis		Multivariate analysis
Variable	HR (95% CI)	P value	HR (95% CI)	P value
Sex^a	0.591 (0.356–0.984)	0.043	0.681 (0.398–1.166)	0.162
Age (years)
<52	Ref		Ref
≥52	1.823 (1.100–3.020)	0.020	2.149 (1.279–3.614)	0.004
Tumor location^b	1.032 (0.607–1.754)	0.908
Pathologic grade
Well differentiated	Ref		Ref
Moderately differentiated	2.483 (1.475–4.183)	0.001	2.417 (1.417–4.124)	0.001
Poorly differentiated	4.728 (2.101–10.639)	<0.001	2.726 (1.172–6.336)	0.020
T category
T1/T2	Ref		Ref
T3/T4	3.575 (2.054–6.223)	<0.001	2.007 (1.091–3.691)	0.025
N category
N0	Ref		Ref
N+	4.846 (2.725–8.618)	<0.001	3.408 (1.873–6.202)	<0.001
Treatment ^c	3.963 (2.451–6.407)	<0.001	2.559 (1.492–4.392)	0.001
MS
With MS	Ref		Ref
Without MS	2.342 (1.070–5.125)	0.033	2.518 (1.126–5.631)	0.024
One component meets the criteria of MS
BMI	0.692 (0.330–1.448)	0.328
GLU	0.938 (0.491–1.792)	0.846
BP	0.745 (0.455–1.221)	0.243
TG	0.695 (0.391–1.235)	0.215
HDL	0.818 (0.491–1.361)	0.439

^aMale versus female; ^bthe margo lateralis linguae versus other locations (the apex linguae, dorsum, and ventrum of the tongue); ^csurgery alone versus multimodality therapy. TSCC, tongue squamous cell carcinoma; HR, hazard ratio; CI, confidence interval; Ref, reference; MS, metabolic syndrome; BMI, body mass index; GLU, fasting plasma glucose; BP, blood pressure; TG, triglycerides; HDL, high-density lipoprotein.

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