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Table 1 Drug sensitivities of ABCB1- and ABCC10-overexpressing cells

From: ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel

Cell line IC 50 of paclitaxel (nmol/L) FR P value IC 50 of cabazitaxel (nmol/L) FR P value
KB-3-1 11.7 ± 2.7 21.2 0.031 13.9 ± 5.5 2.2 0.114
KB-C2 249.4 ± 60.9 31.2 ± 7.1
LLC-PK1 30.5 ± 2.2 25.6 0.004 27.9 ± 0.7 9.1 0.001
LLC-MDR1-WT 781.9 ± 70.2 255.1 ± 12.2
HEK293/pcDNA3.1 12.8 ± 1.4 9.3 0.010 12.5 ± 2.1 1.0 0.799
HEK293/ABCC10 119.2 ± 15.7 13.1 ± 1.8
  1. IC50, 50% inhibition concentration; FR, fold resistance. All IC50 values are expressed as the mean ± standard deviation (SD). FR was calculated by dividing the IC50 values of paclitaxel or cabazitaxel for resistant cells (KB-C2, LLC-MDR1-WT, or HEK293/ABCC10 cells) by those for the parental sensitive cells (KB-3-1, LLC-PK1, or HEK293/pcDNA3.1 cells, respectively). The values in the table are representative of at least 3 independent experiments.