ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel

Cancer Communications

Table 1 Drug sensitivities of ABCB1- and ABCC10-overexpressing cells

Cell line	IC ₅₀ of paclitaxel (nmol/L)	FR	P value	IC ₅₀ of cabazitaxel (nmol/L)	FR	P value
KB-3-1	11.7 ± 2.7	21.2	0.031	13.9 ± 5.5	2.2	0.114
KB-C2	249.4 ± 60.9	21.2	0.031	31.2 ± 7.1	2.2	0.114
LLC-PK1	30.5 ± 2.2	25.6	0.004	27.9 ± 0.7	9.1	0.001
LLC-MDR1-WT	781.9 ± 70.2	25.6	0.004	255.1 ± 12.2	9.1	0.001
HEK293/pcDNA3.1	12.8 ± 1.4	9.3	0.010	12.5 ± 2.1	1.0	0.799
HEK293/ABCC10	119.2 ± 15.7	9.3	0.010	13.1 ± 1.8	1.0	0.799

IC₅₀, 50% inhibition concentration; FR, fold resistance. All IC₅₀ values are expressed as the mean ± standard deviation (SD). FR was calculated by dividing the IC₅₀ values of paclitaxel or cabazitaxel for resistant cells (KB-C2, LLC-MDR1-WT, or HEK293/ABCC10 cells) by those for the parental sensitive cells (KB-3-1, LLC-PK1, or HEK293/pcDNA3.1 cells, respectively). The values in the table are representative of at least 3 independent experiments.