Cell line
|
IC
50
of paclitaxel (nmol/L)
|
FR
|
P
value
|
IC
50
of cabazitaxel (nmol/L)
|
FR
|
P
value
|
---|
KB-3-1
|
11.7 ± 2.7
|
21.2
|
0.031
|
13.9 ± 5.5
|
2.2
|
0.114
|
KB-C2
|
249.4 ± 60.9
|
31.2 ± 7.1
|
LLC-PK1
|
30.5 ± 2.2
|
25.6
|
0.004
|
27.9 ± 0.7
|
9.1
|
0.001
|
LLC-MDR1-WT
|
781.9 ± 70.2
|
255.1 ± 12.2
|
HEK293/pcDNA3.1
|
12.8 ± 1.4
|
9.3
|
0.010
|
12.5 ± 2.1
|
1.0
|
0.799
|
HEK293/ABCC10
|
119.2 ± 15.7
|
13.1 ± 1.8
|
- IC50, 50% inhibition concentration; FR, fold resistance. All IC50 values are expressed as the mean ± standard deviation (SD). FR was calculated by dividing the IC50 values of paclitaxel or cabazitaxel for resistant cells (KB-C2, LLC-MDR1-WT, or HEK293/ABCC10 cells) by those for the parental sensitive cells (KB-3-1, LLC-PK1, or HEK293/pcDNA3.1 cells, respectively). The values in the table are representative of at least 3 independent experiments.