|
Variable
|
No. of studies
|
Sample size (cases/controls)
|
Homozygous
|
Heterozygous
|
Recessive
|
Dominant
|
Allele comparison
|
|---|
|
OR (95% CI)
|
P
het
|
OR (95% CI)
|
P
het
|
OR (95% CI)
|
P
het
|
OR (95% CI)
|
P
het
|
OR (95% CI)
|
P
het
|
|---|
|
Asp312Asn polymorphism
|
AA vs. GG
|
GA vs. GG
|
AA vs. (GA + GG)
|
(GA + AA) vs. GG
|
A vs. G
|
|
All
|
6
|
3,095/3,306
|
1.11 (0.94-1.32)
|
0.718
|
1.00 (0.89-1.11)
|
0.935
|
1.12 (0.95-1.31)
|
0.368
|
1.02 (0.92-1.13)
|
0.426
|
1.04 (0.96-1.12)
|
0.717
|
|
Ethnicity
|
|
Caucasian
|
3
|
1,596/1,833
|
1.10 (0.88-1.37)
|
0.580
|
1.00 (0.87-1.16)
|
0.073
|
1.09 (0.89-1.34)
|
0.156
|
1.02 (0.89-1.17)
|
0.315
|
1.03 (0.93-1.14)
|
0.986
|
|
Asian
|
1
|
307/303
|
1.38 (0.31-6.23)
|
NA
|
1.39 (0.87-2.22)
|
NA
|
1.32 (0.29-5.95)
|
NA
|
1.39 (0.88-2.19)
|
NA
|
1.36 (0.89-2.07)
|
NA
|
|
Mixed
|
2
|
1,192/1,170
|
1.12 (0.86-1.46)
|
0.192
|
0.94 (0.79-1.12)
|
0.687
|
1.16 (0.90-1.50)
|
0.217
|
0.98 (0.83-1.15)
|
0.450
|
1.02 (0.90-1.15)
|
0.267
|
|
Source of the controls
|
|
PB
|
5
|
2,788/3,003
|
1.11 (0.94-1.32)
|
0.591
|
0.98 (0.88-1.09)
|
0.223
|
1.12 (0.95-1.31)
|
0.252
|
1.00 (0.91-1.12)
|
0.549
|
1.03 (0.95-1.11)
|
0.864
|
|
HB
|
1
|
307/303
|
1.38 (0.31-6.23)
|
NA
|
1.39 (0.87-1.22)
|
NA
|
1.32 (0.29-5.95)
|
NA
|
1.39 (0.88-2.19)
|
NA
|
1.36 (0.89-2.07)
|
NA
|
|
NHL subtype
|
|
DLBCL
|
4
|
726/2,170
|
1.00 (0.73-1.37)
|
0.829
|
0.98 (0.80-1.18)
|
0.667
|
1.01 (0.75-1.37)
|
0.669
|
1.02 (0.86-1.22)
|
0.463
|
0.99 (0.86-1.14)
|
0.998
|
|
FL
|
5
|
1,088/2,772
|
1.12 (0.88-1.42)
|
0.595
|
1.00 (0.85-1.17)
|
0.059
|
1.10 (0.88-1.38)
|
0.194
|
1.03 (0.89-1.20)
|
0.297
|
1.04 (0.93-1.16)
|
0.732
|
|
Lys751Gln polymorphism
|
CC vs. AA
|
AC vs. AA
|
C/C vs. (AC + AA)
|
(AC + CC) vs. AA
|
C vs. A
|
|
All
|
7
|
3,249/3,676
|
0.97 (0.83-1.15)
|
0.428
|
0.96 (0.86-1.06)
|
0.184
|
1.00 (0.86-1.16)
|
0.200
|
0.96 (0.87-1.06)
|
0.335
|
0.98 (0.91-1.05)
|
0.405
|
|
Ethnicity
|
|
Caucasian
|
3
|
1,666/1,848
|
0.88 (0.72-1.09)
|
0.305
|
0.99 (0.86-1.14)
|
0.255
|
0.88 (0.72-1.07)
|
0.137
|
0.96 (0.84-1.10)
|
0.482
|
0.95 (0.86-1.05)
|
0.522
|
|
Asian
|
2
|
381/659
|
1.85 (0.53-6.47)
|
0.823
|
1.15 (0.76-1.73)
|
0.159
|
1.81 (0.52-6.33)
|
0.777
|
1.20 (0.81-1.78)
|
0.184
|
1.23 (0.85-1.77)
|
0.232
|
|
Mixed
|
2
|
1,202/1,169
|
1.11 (0.85-1.44)
|
0.397
|
0.88 (0.74-1.05)
|
0.140
|
1.19 (0.93-1.52)
|
0.718
|
0.93 (0.79-1.09)
|
0.140
|
1.00 (0.89-1.13)
|
0.227
|
|
Source of the controls
|
|
PB
|
5
|
2,868/3,017
|
0.96 (0.82-1.13)
|
0.307
|
0.94 (0.84-1.05)
|
0.205
|
0.99 (0.85-1.15)
|
0.111
|
0.95 (0.85-1.05)
|
0.438
|
0.97 (0.90-1.04)
|
0.530
|
|
HB
|
2
|
381/659
|
1.85 (0.53-6.47)
|
0.823
|
1.15 (0.76-1.73)
|
0.159
|
1.81 (0.52-6.33)
|
0.777
|
1.20 (0.81-1.78)
|
0.184
|
1.23 (0.85-1.77)
|
0.232
|
|
NHL subtype
|
|
DLBCL
|
5
|
946/2,731
|
0.96 (0.74-1.24)
|
0.003
|
0.90 (0.76-1.07)
|
0.213
|
1.01 (0.79-1.29)
|
0.005
|
0.95 (0.81-1.11)
|
0.042
|
0.96 (0.85-1.08)
|
0.005
|
|
FL
|
6
|
1,227/3,322
|
0.87 (0.69-1.08)
|
0.522
|
0.95 (0.82-1.11)
|
0.234
|
0.88 (0.72-1.09)
|
0.227
|
0.95 (0.82-1.09)
|
0.448
|
0.93 (0.84-1.03)
|
0.681
|
- OR, odds ratio; CI, confidence interval; P
het, P value for heterogeneity; NA, not applicable; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma. Other abbreviations as in Table 1.
