Variable | No. of studies | Sample size (cases/controls) | Homozygous | Heterozygous | Recessive | Dominant | Allele comparison | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | OR (95% CI) | P het | |||
Asp312Asn polymorphism | AA vs. GG | GA vs. GG | AA vs. (GA + GG) | (GA + AA) vs. GG | A vs. G | |||||||
All | 6 | 3,095/3,306 | 1.11 (0.94-1.32) | 0.718 | 1.00 (0.89-1.11) | 0.935 | 1.12 (0.95-1.31) | 0.368 | 1.02 (0.92-1.13) | 0.426 | 1.04 (0.96-1.12) | 0.717 |
Ethnicity | ||||||||||||
Caucasian | 3 | 1,596/1,833 | 1.10 (0.88-1.37) | 0.580 | 1.00 (0.87-1.16) | 0.073 | 1.09 (0.89-1.34) | 0.156 | 1.02 (0.89-1.17) | 0.315 | 1.03 (0.93-1.14) | 0.986 |
Asian | 1 | 307/303 | 1.38 (0.31-6.23) | NA | 1.39 (0.87-2.22) | NA | 1.32 (0.29-5.95) | NA | 1.39 (0.88-2.19) | NA | 1.36 (0.89-2.07) | NA |
Mixed | 2 | 1,192/1,170 | 1.12 (0.86-1.46) | 0.192 | 0.94 (0.79-1.12) | 0.687 | 1.16 (0.90-1.50) | 0.217 | 0.98 (0.83-1.15) | 0.450 | 1.02 (0.90-1.15) | 0.267 |
Source of the controls | ||||||||||||
PB | 5 | 2,788/3,003 | 1.11 (0.94-1.32) | 0.591 | 0.98 (0.88-1.09) | 0.223 | 1.12 (0.95-1.31) | 0.252 | 1.00 (0.91-1.12) | 0.549 | 1.03 (0.95-1.11) | 0.864 |
HB | 1 | 307/303 | 1.38 (0.31-6.23) | NA | 1.39 (0.87-1.22) | NA | 1.32 (0.29-5.95) | NA | 1.39 (0.88-2.19) | NA | 1.36 (0.89-2.07) | NA |
NHL subtype | ||||||||||||
DLBCL | 4 | 726/2,170 | 1.00 (0.73-1.37) | 0.829 | 0.98 (0.80-1.18) | 0.667 | 1.01 (0.75-1.37) | 0.669 | 1.02 (0.86-1.22) | 0.463 | 0.99 (0.86-1.14) | 0.998 |
FL | 5 | 1,088/2,772 | 1.12 (0.88-1.42) | 0.595 | 1.00 (0.85-1.17) | 0.059 | 1.10 (0.88-1.38) | 0.194 | 1.03 (0.89-1.20) | 0.297 | 1.04 (0.93-1.16) | 0.732 |
Lys751Gln polymorphism | CC vs. AA | AC vs. AA | C/C vs. (AC + AA) | (AC + CC) vs. AA | C vs. A | |||||||
All | 7 | 3,249/3,676 | 0.97 (0.83-1.15) | 0.428 | 0.96 (0.86-1.06) | 0.184 | 1.00 (0.86-1.16) | 0.200 | 0.96 (0.87-1.06) | 0.335 | 0.98 (0.91-1.05) | 0.405 |
Ethnicity | ||||||||||||
Caucasian | 3 | 1,666/1,848 | 0.88 (0.72-1.09) | 0.305 | 0.99 (0.86-1.14) | 0.255 | 0.88 (0.72-1.07) | 0.137 | 0.96 (0.84-1.10) | 0.482 | 0.95 (0.86-1.05) | 0.522 |
Asian | 2 | 381/659 | 1.85 (0.53-6.47) | 0.823 | 1.15 (0.76-1.73) | 0.159 | 1.81 (0.52-6.33) | 0.777 | 1.20 (0.81-1.78) | 0.184 | 1.23 (0.85-1.77) | 0.232 |
Mixed | 2 | 1,202/1,169 | 1.11 (0.85-1.44) | 0.397 | 0.88 (0.74-1.05) | 0.140 | 1.19 (0.93-1.52) | 0.718 | 0.93 (0.79-1.09) | 0.140 | 1.00 (0.89-1.13) | 0.227 |
Source of the controls | ||||||||||||
PB | 5 | 2,868/3,017 | 0.96 (0.82-1.13) | 0.307 | 0.94 (0.84-1.05) | 0.205 | 0.99 (0.85-1.15) | 0.111 | 0.95 (0.85-1.05) | 0.438 | 0.97 (0.90-1.04) | 0.530 |
HB | 2 | 381/659 | 1.85 (0.53-6.47) | 0.823 | 1.15 (0.76-1.73) | 0.159 | 1.81 (0.52-6.33) | 0.777 | 1.20 (0.81-1.78) | 0.184 | 1.23 (0.85-1.77) | 0.232 |
NHL subtype | ||||||||||||
DLBCL | 5 | 946/2,731 | 0.96 (0.74-1.24) | 0.003 | 0.90 (0.76-1.07) | 0.213 | 1.01 (0.79-1.29) | 0.005 | 0.95 (0.81-1.11) | 0.042 | 0.96 (0.85-1.08) | 0.005 |
FL | 6 | 1,227/3,322 | 0.87 (0.69-1.08) | 0.522 | 0.95 (0.82-1.11) | 0.234 | 0.88 (0.72-1.09) | 0.227 | 0.95 (0.82-1.09) | 0.448 | 0.93 (0.84-1.03) | 0.681 |